Description
Cefoxitin is a cephamycin antibiotic grouped with the second generation cephalosporins. It is effective against gram-positive and gram-negative bacteria and is especially effective against anaerobic bacteria. Cefoxitin is resistant to degradation by β-lactamases.
Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.
Product Specifications
Cefoxitin
MOLECULAR BIOLOGY GRADE
Formula: C16H17N3O7S2
MW: 427.45 g/mol
Storage/Handling: Store at -20°C.
PubChem Chemical ID: 441199
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