Erythromycin is a macrolide antibiotic isolated from Streptomyces erythreus. It displays strong efficacy against gram-positive cocci and bacilli and some mycobacteria, mycoplasma, and spirochetes. In addition to its antimicrobial properties, erythromycin is a motilin receptor agonist that has been shown to inhibit respiratory glycoconjugate secretion in vitro. Erythromycin estolate is freely soluble in organic solvents.
Macrolide antibiotics are composed of a macrocyclic lactone ring attached to one or more deoxy sugars. They inhibit bacterial protein synthesis by irreversibly binding the P site of the 50s ribosome, preventing peptide bond formation and translocation.
Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
MOLECULAR BIOLOGY GRADE
Formula: C40H71NO14 ∙ C12H26SO4
MW: 1,056.39 g/mol
Storage/Handling: Store at 2-8°C. This product is light sensitive.
PubChem Chemical ID: 441371
|Grade||MOLECULAR BIOLOGY GRADE|
|Storage/Handling||Store at 4°C.|