Description
Piperacillin is an extended-spectrum β-lactam antibiotic resistant to many β-lactamases. It is derived from ampicillin and targets gram-negative and gram-positive bacteria. Additionally, piperacillin has been used in studies on optimization of antimicrobial therapy in patients with sepsis and to study piperacillin allergic reactions. It has also been used to study multidrug resistant organisms.
Penicillins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a five-membered thiazolidine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Resistance to β-lactam antibiotics occurs in the presence of cells containing plasmid encoded extended spectrum β-lactamases or ESBLs.
Product Specifications
Piperacillin
MOLECULAR BIOLOGY GRADE
Formula: C23H27N5O7S
MW: 517.55 g/mol
Storage/Handling: Store at 2-8°C.
PubChem Chemical ID: 43672
