Cefamandole Sodium Salt

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Description

Cefamandole sodium salt is a second generation cephalosporin antibiotic. It is effective against a variety of gram-negative and gram-positive bacteria. It has been used to study the expression and inhibition of the penicillin binding proteins, especially PBP 2A. Cefamandole sodium salt is freely soluble in aqueous solution.

Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.


Product Specifications
Cefamandole Sodium Salt

MOLECULAR BIOLOGY GRADE

Formula: C18H17N6NaO5S2

MW: 484.48 g/mol

Storage/Handling: Store at 4°C.

PubChem Chemical ID: 23672568

Cefamandole Sodium Salt

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Catalog Number:
C-561-100
CAS Number:
30034-03-8
$172.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
2-3 Weeks
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Cefamandole sodium salt is a second generation cephalosporin antibiotic. It is effective against a variety of gram-negative and gram-positive bacteria. It has been used to study the expression and inhibition of the penicillin binding proteins, especially PBP 2A. Cefamandole sodium salt is freely soluble in aqueous solution.

    Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.


    Product Specifications
    Cefamandole Sodium Salt

    MOLECULAR BIOLOGY GRADE

    Formula: C18H17N6NaO5S2

    MW: 484.48 g/mol

    Storage/Handling: Store at 4°C.

    PubChem Chemical ID: 23672568

    Product Specifications

    Catalog ID: C-561
    CAS #: 30034-03-8
    MW: 484.48 g/mol
    Grade: MOLECULAR BIOLOGY GRADE
    Storage/handling: Store at 4°C.
    PubChem Chemical ID: 23672568
    IUPAC Name: sodium (6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    InChI: InChI=1S/C18H18N6O5S2.Na/c1-23-18(20-21-22-23)31-8-10-7-30-16-11(15(27)24(16)12(10)17(28)29)19-14(26)13(25)9-5-3-2-4-6-9;/h2-6,11,13,16,25H,7-8H2,1H3,(H,19,26)(H,28,29);/q;+1/p-1/t11-,13-,16-;/m1./s1
    InChIKey: OJMNTWPPFNMOCJ-CFOLLTDRSA-M
    SMILES: CN1C(=NN=N1)SCC2=C(N3C(C(C3=O)NC(=O)C(C4=CC=CC=C4)O)SC2)C(=O)[O-].[Na+]

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