Description
CXCL5 is an ELR type of CXC chemokine. It is expressed in various epithelial cell lines alongside CXCL8 (IL8) and CXCL1 in response to stimulation by IL1 or TNF-alpha. It is down regulated by IFN-gamma. Like many CXC chemokines, CXCL5 is a ligand for CXCR2. It is a chemoattractant and activator of neutrophils, and plays a role in angiogenesis and inflammation, as well as the metastasis of various cancers. It also blocks insulin signaling by activating the JAK2/STAT5/SOCS2 pathway.
Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Recombinant Human Chemokine (C-X-C motif) Ligand 5 (CXCL5)
Epithelial-derived Neutrophil Activating Peptide 78 (ENA78, ENA-78)
Lipopolysaccharide (LPS) Induced CXC Chemokine (LIX)
Small Inducible Cytokine Subfamily B Member 5 (SCYB5)
Source: Escherichia coli
MW: ~8.1 kDa (74 amino acids)
Purity: >97% by SDS-PAGE and HPLC analyses
Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration of 5-10 ng/ml.
Storage/Handling: Store desiccated at -20°C.
HGNC: 10642
NOT FOR HUMAN USE!
Additional resources for this protein may be found at:
OMIM
