Cefsulodin (SCE-129)

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Description

Cefsulodin is a third generation cephalosporin antibiotic used as a selective agent in isolation media such as Yersinia Selective Agar, Columbia Blood Agar, Salmonella Chromogenic Agar, and CIN Agar. It is mildly effective against gram-positive and gram-negative bacteria, but exhibits greater efficacy against Pseudomonas aeruginosa. In addition to its antimicrobial properties, cefsulodin is a substrate for the rat Oatp1a4 transporter.

Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.



Product Specifications
Cefsulodin (SCE-129)
Cefomonil
Pseudocef

MOLECULAR BIOLOGY GRADE

Formula: C22H19N4O8S2Na

MW: 554.53 g/mol

Color/Purity:Off-white to slightly yellow crystalline powder

PubChem Chemical ID: 656644

Storage/Handling:Store desiccated at -20°C, and protect from light.

Cefsulodin (SCE-129)

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Catalog Number:
C-114-1
CAS Number:
52152-93-9
$126.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
In stock
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Cefsulodin is a third generation cephalosporin antibiotic used as a selective agent in isolation media such as Yersinia Selective Agar, Columbia Blood Agar, Salmonella Chromogenic Agar, and CIN Agar. It is mildly effective against gram-positive and gram-negative bacteria, but exhibits greater efficacy against Pseudomonas aeruginosa. In addition to its antimicrobial properties, cefsulodin is a substrate for the rat Oatp1a4 transporter.

    Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.



    Product Specifications
    Cefsulodin (SCE-129)
    Cefomonil
    Pseudocef

    MOLECULAR BIOLOGY GRADE

    Formula: C22H19N4O8S2Na

    MW: 554.53 g/mol

    Color/Purity:Off-white to slightly yellow crystalline powder

    PubChem Chemical ID: 656644

    Storage/Handling:Store desiccated at -20°C, and protect from light.

    Product Specifications

    Catalog ID: C-114
    CAS #: 52152-93-9
    MW: 554.53 g/mol
    Grade: MOLECULAR BIOLOGY GRADE
    Storage/handling: Store desiccated at -20°C. Protect from light.
    PubChem Chemical ID: 656644
    IUPAC Name: sodium (6R,7R)-3-[(4-carbamoylpyridin-1-ium-1-yl)methyl]-8-oxo-7-[[(2R)-2-phenyl-2-sulfonatoacetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    InChI: InChI=1S/C22H20N4O8S2.Na/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12;/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34);/q;+1/p-1/t15-,17-,21-;/m1./s1
    InChIKey: REACMANCWHKJSM-DWBVFMGKSA-M
    SMILES: C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)S(=O)(=O)[O-])C(=O)[O-])C[N+]4=CC=C(C=C4)C(=O)N.[Na+]

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