Description
Brefeldin A is an antibiotic derived from Penicillium brefeldianum. It is an anti-cancer agent which disrupts protein transport and causes apoptosis of tumor cells. Brefeldin A disrupts the function of the Golgi apparatus and blocks Golgi-COPI activity. ER vesicles are prevented from fusion with the Golgi and are secretion is inhibited. Additionally, Brefeldin A is an ARF inhibitor, sphingomyelin cycle activator, and caspase-3 activator. It has been shown to induce apoptosis in leukemia cells and colon cancer cells.
Product Specifications
Brefeldin A
MOLECULAR BIOLOGY GRADE
Formula: C16H24O4
MW: 280.36 g/mol
Storage/Handling: Store at 4°C.
Brefeldin A is soluble in DMSO, acetone, or ethanol. It is insoluble in water.
PubChem CID: 5287620
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