Description
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Recombinant Rhesus Monkey Chemokine (C-C motif) Ligand 11 (CCL11)
Eotaxin, Eotaxin 1
Small Inducible Cytokine Subfamily A Member 11 (SCYA11)
CCL11 is a chemokine containing four conserved cysteine residues, the first two of which are adjacent. It is expressed in dermal fibroblasts. Expression of CCL11 is induced by IL1A and TNFA and inhibited by IFNG. It is strongly and selectively chemotactic for eosinophils and induces a calcium flux response in eosinophils. CCL11 induces angiogenesis and endothelial cell sprouting from aortic rings in the absence of an eosinophil and has been implicated to be involved in a variety of eosinophilic inflammatory diseases. CCL11 is a ligand for CCR1, CCR2, CCR3, CCR5, and ACKR2 (D6).
Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.
Source: Escherichia coli
MW: ~8.4 kDa (74 amino acids)
Purity: >98% by SDS-PAGE and HPLC analyses
Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration of 0.1-10 ng/ml.
Storage/Handling: Store desiccated at -20°C.
NCBI: 6356
NOT FOR HUMAN USE!
Additional resources for this protein may be found at:
OMIM
