Description
Cefmetazole free acid is a second generation cephalosporin antibiotic that has a broad range of activity against gram-negative and gram-positive bacterium. Cefmetazole has exhibited great bactericidal activity against Staphylococcus aureus, which includes some methicillin-resistant strains.
Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.
Product Specifications
Cefmetazole free acid
Formula: C15H17N7O5S3
MW: 471.53 g/mol
Storage/Handling: Store desiccated at -20°C.
PubChem Chemical ID: 42008
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