Description
Cefoperazone is a third generation cephalosporin antibiotic primarily targeting P. aeruginosa and other gram-negative bacteria. It has also been used to study penicillin binding proteins (PBPs) and is a β-lactamase inhibitor. Cefoperazone sodium is freely soluble in aqueous solution.
Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.
Product Specifications
Cefoperazone Sodium, USP Grade
Formula: C25H26N9NaO8S2
MW: 667.65 g/mol
Storage/Handling: Store at 4°C. Protect from light and air.
PubChem Chemical ID: 23663974
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