Description
GoldBio's Cefotaxime (Sodium) Solution is supplied as a ready-to-use 250 mg/mL stock solution for researchers needing a more concentrated antibiotic stock. The higher concentration allows smaller volumes to be added to media and culture preparations, reducing dilution while providing greater flexibility when preparing a wide range of working concentrations.
By eliminating the need to weigh, dissolve, and filter sterilize antibiotic powder, the solution also saves preparation time and helps improve consistency from experiment to experiment.
Cefotaxime is a third generation, broad-spectrum cephalosporin antibiotic effective against various gram-negative and gram-positive bacteria. However, unlike many other cephalosporins, cefotaxime is not effective against Pseudomonas aeruginosa bacteria. Cefotaxime is often used in Agrobacterium tumefaciens-mediated transformations to regulate bacterial growth. It has been shown to exhibit a synergistic effect with Vancomycin in certain conditions.
Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.
GoldBio’s antibiotic solutions are provided ready to use.
Product Specifications:
Cefotaxime Sodium in H 2O
250 mg/mL Premade Solution, 0.2 µm Sterile Filtered
MOLECULAR BIOLOGY GRADE
Formula: NaC 16H16N5O7S2
MW: 477.45 g/mol
Storage/Handling: Store at -20°C.
PubChem Chemical ID: 10695961
