Description
Cefotetan disodium is a semi-synthetic β-lactam antibiotic that is classified as a second generation cephalosporin. Cefotetan disodium effects a broad range of gram positive and gram negative bacteria. It has also displayed a significant degree of bactericidal activity towards aerobic and anaerobic bacteria.
Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.
Product Specifications
Cefotetan disodium
Formula: C17H15N7Na2O8S4
MW: 619.58 g/mol
Storage/Handling: Store at -20°C. Protect from light.
PubChem Chemical ID: 53024
