Cefotetan disodium

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Description

Cefotetan disodium is a semi-synthetic β-lactam antibiotic that is classified as a second generation cephalosporin. Cefotetan disodium effects a broad range of gram positive and gram negative bacteria. It has also displayed a significant degree of bactericidal activity towards aerobic and anaerobic bacteria.

Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.


Product Specifications
Cefotetan disodium

Formula: C17H15N7Na2O8S4

MW: 619.58 g/mol

Storage/Handling: Store at -20°C. Protect from light.

PubChem Chemical ID: 53024

Cefotetan disodium

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Catalog Number:
C-715-100
CAS Number:
74356-00-6
$95.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
2-3 Weeks
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Cefotetan disodium is a semi-synthetic β-lactam antibiotic that is classified as a second generation cephalosporin. Cefotetan disodium effects a broad range of gram positive and gram negative bacteria. It has also displayed a significant degree of bactericidal activity towards aerobic and anaerobic bacteria.

    Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.


    Product Specifications
    Cefotetan disodium

    Formula: C17H15N7Na2O8S4

    MW: 619.58 g/mol

    Storage/Handling: Store at -20°C. Protect from light.

    PubChem Chemical ID: 53024

    Product Specifications

    Catalog ID: C-715
    CAS #: 74356-00-6
    MW: 619.58 g/mol
    Storage/handling: Store desiccated at -20°C.
    PubChem Chemical ID: 53024
    IUPAC Name: disodium;(6R,7S)-7-[[4-(2-amino-1-carboxylato-2-oxoethylidene)-1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    InChI: InChI=1S/C17H17N7O8S4.2Na/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28;;/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30);;/q;2*+1/p-2/t13?,15-,17+;;/m1../s1
    InChIKey: ZQQALMSFFARWPK-ZTQQJVKJSA-L
    SMILES: CN1C(=NN=N1)SCC2=C(N3C(C(C3=O)(NC(=O)C4SC(=C(C(=O)N)C(=O)[O-])S4)OC)SC2)C(=O)[O-].[Na+].[Na+]

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