Cefotiam HCl

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Description

Cefotiam is a second generation cephalosporin antibiotic effective against gram-negative and gram-positive bacteria. However, it is not effective against Pseudomonas aeruginosa. Cefotiam has been used as a prophylactic antibiotic against methicillin-resistant Staphylococcus aureus or MRSA. It is soluble in aqueous solution.

Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.


Product Specifications
Cefotiam HCl
Cefotiam Hydrochloride

MOLECULAR BIOLOGY GRADE

Formula: C18H23N9O4S3 ∙ HCl

MW: 562.09 g/mol

Storage/Handling: Store at 2-8 °C.

PubChem Chemical ID: 20848883

Cefotiam HCl

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Catalog Number:
C-681-50
CAS Number:
66309-69-1
$165.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
2-3 Weeks
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Cefotiam is a second generation cephalosporin antibiotic effective against gram-negative and gram-positive bacteria. However, it is not effective against Pseudomonas aeruginosa. Cefotiam has been used as a prophylactic antibiotic against methicillin-resistant Staphylococcus aureus or MRSA. It is soluble in aqueous solution.

    Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.


    Product Specifications
    Cefotiam HCl
    Cefotiam Hydrochloride

    MOLECULAR BIOLOGY GRADE

    Formula: C18H23N9O4S3 ∙ HCl

    MW: 562.09 g/mol

    Storage/Handling: Store at 2-8 °C.

    PubChem Chemical ID: 20848883

    Product Specifications

    Catalog ID: C-681
    CAS #: 66309-69-1
    MW: 562.09 g/mol
    Grade: MOLECULAR BIOLOGY GRADE
    Storage/handling: Store at 4°C.
    PubChem Chemical ID: 47896
    IUPAC Name: (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;dihydrochloride
    InChI: InChI=1S/C18H23N9O4S3.2ClH/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10;;/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31);2*1H/t12-,15-;;/m1../s1
    InChIKey: BWRRTAXZCKVRON-DGPOFWGLSA-N
    SMILES: CN(C)CCN1C(=NN=N1)SCC2=C(N3C(C(C3=O)NC(=O)CC4=CSC(=N4)N)SC2)C(=O)O.Cl.Cl

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