Description
Cefpirome is a fourth generation cephalosporin antibiotic targeting gram-positive and gram-negative bacteria. Is it not effective against many Bacteroides, Enterococci, and Haemophili species due to the resistance they have developed. Cefpirome sulfate with sodium carbonate is a mixture of cefpirome sulfate and anhydrous sodium carbonate and is commonly used for the stabilization of pH.
Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.
Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
Product Specifications
Cefpirome Sulfate with Sodium Carbonate
MOLECULAR BIOLOGY GRADE
Formula: C22H22N6O5S2 • H2SO4 and Na2CO3
MW: 612.66 g/mol (cefpirome sulfate) + 105.99 g/mol (sodium bicarbonate)
Storage/Handling: Store at 2-8 °C.
