Description
Cefpodoxime proxetil is a third generation cephalosporin antibiotic targeting a wide variety of gram-negative and gram-positive organisms, especially those responsible for otitis media and pharyngitis. It is an ester prodrug of the free acid metabolite cefpodoxime.
Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.
Product Specifications
Cefpodoxime Proxetil
Vantin® (Pfizer), Simplicef® (Pfizer)
MOLECULAR BIOLOGY GRADE
Formula: C21H27N5O9S2
MW: 557.60 g/mol
Storage/Handling: Store at 2-8 °C. This product is light sensitive. Soluble in DMSO.
PubChem Chemical ID: 6526396
