Cefradine

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Description

Cefradine (also known as cephradine) is a first generation cephalosporin antibiotic similar to cephalexin. It targets both gram-negative and gram-positive bacteria. In addition, cefradine has been used to study penicillin binding proteins, especially PBP3.

Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.


Product Specifications
Cefradine
Cephradine

MOLECULAR BIOLOGY GRADE

Formula: C16H19N3O4S

MW: 349.40 g/mol

Storage/Handling: Store at 2-8°C.

PubChem Chemical ID: 38103

Cefradine

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Catalog Number:
C-730-500
CAS Number:
38821-53-3
$145.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
2-3 Weeks
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Cefradine (also known as cephradine) is a first generation cephalosporin antibiotic similar to cephalexin. It targets both gram-negative and gram-positive bacteria. In addition, cefradine has been used to study penicillin binding proteins, especially PBP3.

    Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.


    Product Specifications
    Cefradine
    Cephradine

    MOLECULAR BIOLOGY GRADE

    Formula: C16H19N3O4S

    MW: 349.40 g/mol

    Storage/Handling: Store at 2-8°C.

    PubChem Chemical ID: 38103

    Product Specifications

    Catalog ID: C-730
    CAS #: 38821-53-3
    MW: 349.40 g/mol
    Grade: MOLECULAR BIOLOGY GRADE
    Storage/handling: Store at 4°C.
    PubChem Chemical ID: 38103
    IUPAC Name: (6R,7R)-7-[[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
    InChI: InChI=1S/C16H19N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1
    InChIKey: RDLPVSKMFDYCOR-UEKVPHQBSA-N
    SMILES: CC1=C(N2C(C(C2=O)NC(=O)C(C3=CCC=CC3)N)SC1)C(=O)O

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