Description
Cefradine (also known as cephradine) is a first generation cephalosporin antibiotic similar to cephalexin. It targets both gram-negative and gram-positive bacteria. In addition, cefradine has been used to study penicillin binding proteins, especially PBP3.
Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.
Product Specifications
Cefradine
Cephradine
MOLECULAR BIOLOGY GRADE
Formula: C16H19N3O4S
MW: 349.40 g/mol
Storage/Handling: Store at 2-8°C.
PubChem Chemical ID: 38103
