Description
Ceftiofur sodium is a third generation cephalosporin antibiotic effective against gram-positive and gram-negative bacteria. Although ceftiofur is resistant to β-lactamase degradation, there are several strains of E. coli known to be unaffected by this antibiotic. It is soluble in aqueous solution.
Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.
Product Specifications
Ceftiofur Sodium
MOLECULAR BIOLOGY GRADE
Formula: C19H16N5NaO7S3
MW: 545.54 g/mol
Storage/Handling: Store at 2-8°C.
PubChem Chemical ID: 23671563
