Description
Cephalexin is a first generation cephalosporin antibiotic most effective against gram-positive cocci. However, it also exhibits efficacy against some gram-negative bacilli. In addition, cephalexin has been used to study the penicillin binding proteins, especially PBP3. Cephalexin hydrate is slightly soluble in aqueous solution.
Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.
Product Specifications
Cephalexin hydrate
Formula: C16H17N3O4S · H2O
MW: 365.40 g/mol
Storage/Handling: Store at 4°C.
PubChem Chemical ID: 27447
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