Cloxacillin Sodium Hydrate

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Description

Cloxacillin sodium hydrate is a sodium salt formed from a chlorinated semisynthetic derivative of penicillin. It has been shown to exhibit significant bactericidal activity against penicillin G-resistant staphylococci.

Penicillins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a five-membered thiazolidine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Resistance to β-lactam antibiotics occurs in the presence of cells containing plasmid encoded extended spectrum β-lactamases or ESBLs.


Product Specifications
Cloxacillin sodium

Formula: C19H17ClN3NaO5S ∙ H2O

MW: 475.88 g/mol

Storage/Handling: Store at 4°C.

PubChem Chemical ID: 23675743

Cloxacillin Sodium Hydrate

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Catalog Number:
C-805-1
CAS Number:
7081-44-9
$61.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
2-3 Weeks
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$14.99 Ground shipping (In continental US only.)

    Description

    Cloxacillin sodium hydrate is a sodium salt formed from a chlorinated semisynthetic derivative of penicillin. It has been shown to exhibit significant bactericidal activity against penicillin G-resistant staphylococci.

    Penicillins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a five-membered thiazolidine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Resistance to β-lactam antibiotics occurs in the presence of cells containing plasmid encoded extended spectrum β-lactamases or ESBLs.


    Product Specifications
    Cloxacillin sodium

    Formula: C19H17ClN3NaO5S ∙ H2O

    MW: 475.88 g/mol

    Storage/Handling: Store at 4°C.

    PubChem Chemical ID: 23675743

    Product Specifications

    Catalog ID: C-805
    CAS #: 7081-44-9
    MW: 475.88 g/mol
    Storage/handling: Store at 4°C.
    PubChem Chemical ID: 23675743
    IUPAC Name: sodium;(2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrate
    InChI: InChI=1S/C19H18ClN3O5S.Na.H2O/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1
    InChIKey: KCUWTKOTPIUBRI-VICXVTCVSA-M
    SMILES: CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].O.[Na+]

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