Description
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Recombinant Human Chemokine (C-X-C motif) Ligand 13 (CXCL13)
B-Lymphocyte Chemoattractant (BLC)
Small Inducible Cytokine Subfamily B Member 13 (SCYB13)
Angie, Angie2
B Cell-Attracting Chemokine 1 (BCA1)
CXCL13 is a CXC chemokine lacking the ELR motif. It is expressed highest in liver tissue, followed by spleen, lymph nodes, appendix, and stomach. It is a ligand for CXCR5 and is selectively chemotactic for B lymphocytes. CXCL13 plays an essential role in the development of lymph nodes and the organization of B cells within lymphoid follicles, but its expression is downregulated within lymphoid tissues by IFN-gamma during immune responses. CXCL13 induces B cells to upregulate lymphotoxin alpha-1-beta-2, leading to CXCL13 expression and creating a positive feedback loop essential for follicular dendritic cell development and homeostasis.
Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.
Source: Escherichia coli
MW: ~10.3 kDa (87 amino acids)
Purity: >97% by SDS-PAGE and HPLC analyses
Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human B cells is in a concentration range of 1-10 ng/ml.
Storage/Handling: Store desiccated at -20°C.
HGNC: 10639
NOT FOR HUMAN USE!
Additional resources for this protein may be found at:
OMIM
