Description
The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.
Cyclosporin A is over 99% pure and soluble in DMSO and ethyl alcohol.
Product Specifications
Cyclosporin A
Formula: C62H111N11O12
MW: 1,202.61 g/mol
Storage/Handling: Store at 2-8°C. Soluble in DMSO and EtOH.
PubChem Chemical ID: 5284373
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