Cyclosporin A

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Description

Cyclosporin A is the best-characterized member of the cyclosporin family and is commonly used in research involving T-cell activation, calcineurin signaling, cyclophilin binding and immunosuppression models. While related cyclosporins such as B and D share the same general cyclic peptide structure, Cyclosporin A is the primary reference compound for studying cyclosporin activity because of its well-established interaction with cyclophilin and the resulting inhibition of calcineurin-dependent signaling.

Structurally related cyclosporins can differ in potency, receptor interactions and biological activity, even when they act through similar pathways. Cyclosporin A is especially useful when researchers need a highly pure, well-documented cyclosporin for experiments focused on lymphocyte signaling, immune response regulation or calcineurin pathway inhibition.

The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.

Cyclosporin A is over 99% pure and soluble in DMSO and ethyl alcohol.

Product Specifications
Cyclosporin A

Formula: C62H111N11O12

MW: 1,202.61 g/mol

Storage/Handling: Store at 2-8°C. Soluble in DMSO and EtOH.

PubChem Chemical ID: 5284373

Cyclosporin A

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Catalog Number:
C-940-100
CAS Number:
59865-13-3
$102.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
2-3 Weeks
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Cyclosporin A is the best-characterized member of the cyclosporin family and is commonly used in research involving T-cell activation, calcineurin signaling, cyclophilin binding and immunosuppression models. While related cyclosporins such as B and D share the same general cyclic peptide structure, Cyclosporin A is the primary reference compound for studying cyclosporin activity because of its well-established interaction with cyclophilin and the resulting inhibition of calcineurin-dependent signaling.

    Structurally related cyclosporins can differ in potency, receptor interactions and biological activity, even when they act through similar pathways. Cyclosporin A is especially useful when researchers need a highly pure, well-documented cyclosporin for experiments focused on lymphocyte signaling, immune response regulation or calcineurin pathway inhibition.

    The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.

    Cyclosporin A is over 99% pure and soluble in DMSO and ethyl alcohol.

    Product Specifications
    Cyclosporin A

    Formula: C62H111N11O12

    MW: 1,202.61 g/mol

    Storage/Handling: Store at 2-8°C. Soluble in DMSO and EtOH.

    PubChem Chemical ID: 5284373

    Product Specifications

    Catalog ID: C-940
    CAS #: 59865-13-3
    Formula: C62H111N11O12
    MW: 1202.61 g/mol
    Storage/handling: Store at 4°C.
    PubChem Chemical ID: 5284373
    IUPAC Name: (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
    InChI: InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
    InChIKey: PMATZTZNYRCHOR-CGLBZJNRSA-N
    SMILES: CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

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