Description
Cyclosporin A is the best-characterized member of the cyclosporin family and is commonly used in research involving T-cell activation, calcineurin signaling, cyclophilin binding and immunosuppression models. While related cyclosporins such as B and D share the same general cyclic peptide structure, Cyclosporin A is the primary reference compound for studying cyclosporin activity because of its well-established interaction with cyclophilin and the resulting inhibition of calcineurin-dependent signaling.
Structurally related cyclosporins can differ in potency, receptor interactions and biological activity, even when they act through similar pathways. Cyclosporin A is especially useful when researchers need a highly pure, well-documented cyclosporin for experiments focused on lymphocyte signaling, immune response regulation or calcineurin pathway inhibition.
The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.
Cyclosporin A is over 99% pure and soluble in DMSO and ethyl alcohol.
Product Specifications
Cyclosporin A
Formula: C62H111N11O12
MW: 1,202.61 g/mol
Storage/Handling: Store at 2-8°C. Soluble in DMSO and EtOH.
PubChem Chemical ID: 5284373
Powered by Bioz