Description
Cyclosporin B is a naturally occurring member of the cyclosporin family of cyclic peptide compounds produced by fungi. Although structurally similar to Cyclosporin A, Cyclosporin B differs by a single amino acid residue, resulting in distinct biological properties and altered interactions with cyclophilin and calcineurin. Because of these differences, Cyclosporin B is frequently used in comparative studies investigating the relationship between cyclosporin structure and biological activity.
Researchers use Cyclosporin B to examine mechanisms of immunosuppression, protein binding, and calcineurin signaling while comparing its activity to the better-characterized Cyclosporin A. Its structural similarity makes it a useful reference compound for studies exploring cyclophilin interactions, T-cell signaling, and the influence of subtle chemical modifications on cyclosporin function.
The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.
Cyclosporin B is soluble in DMSO and ethyl alcohol.
Product Specifications
Cyclosporin B
Formula: C61H109N11O12
MW: 1,188.58 g/mol
Storage/Handling: Store at 2-8°C. Soluble in DMSO and EtOH.
PubChem Chemical ID: 6450331
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