Cyclosporin B

Request Lot Specific COA

Citation Search Tool

Description

Cyclosporin B is a naturally occurring member of the cyclosporin family of cyclic peptide compounds produced by fungi. Although structurally similar to Cyclosporin A, Cyclosporin B differs by a single amino acid residue, resulting in distinct biological properties and altered interactions with cyclophilin and calcineurin. Because of these differences, Cyclosporin B is frequently used in comparative studies investigating the relationship between cyclosporin structure and biological activity.

Researchers use Cyclosporin B to examine mechanisms of immunosuppression, protein binding, and calcineurin signaling while comparing its activity to the better-characterized Cyclosporin A. Its structural similarity makes it a useful reference compound for studies exploring cyclophilin interactions, T-cell signaling, and the influence of subtle chemical modifications on cyclosporin function.

 

 

The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.

Cyclosporin B is soluble in DMSO and ethyl alcohol.

Product Specifications
Cyclosporin B

Formula: C61H109N11O12

MW: 1,188.58 g/mol

Storage/Handling: Store at 2-8°C. Soluble in DMSO and EtOH.

PubChem Chemical ID: 6450331

Cyclosporin B

View Sizes & Pricing

Catalog Number:
C-942-5
CAS Number:
63775-95-1
$326.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
2-3 Weeks
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Cyclosporin B is a naturally occurring member of the cyclosporin family of cyclic peptide compounds produced by fungi. Although structurally similar to Cyclosporin A, Cyclosporin B differs by a single amino acid residue, resulting in distinct biological properties and altered interactions with cyclophilin and calcineurin. Because of these differences, Cyclosporin B is frequently used in comparative studies investigating the relationship between cyclosporin structure and biological activity.

    Researchers use Cyclosporin B to examine mechanisms of immunosuppression, protein binding, and calcineurin signaling while comparing its activity to the better-characterized Cyclosporin A. Its structural similarity makes it a useful reference compound for studies exploring cyclophilin interactions, T-cell signaling, and the influence of subtle chemical modifications on cyclosporin function.

     

     

    The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.

    Cyclosporin B is soluble in DMSO and ethyl alcohol.

    Product Specifications
    Cyclosporin B

    Formula: C61H109N11O12

    MW: 1,188.58 g/mol

    Storage/Handling: Store at 2-8°C. Soluble in DMSO and EtOH.

    PubChem Chemical ID: 6450331

    Product Specifications

    Catalog ID: C-942
    CAS #: 63775-95-1
    Formula: C61H109N11O12
    MW: 1188.58 g/mol
    Storage/handling: Store at 4°C.
    PubChem Chemical ID: 12797522
    IUPAC Name: (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28,30-decamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
    InChI: InChI=1S/C61H109N11O12/c1-25-26-27-39(14)51(74)50-55(78)64-41(16)56(79)66(18)32-47(73)67(19)43(28-33(2)3)54(77)65-48(37(10)11)60(83)68(20)44(29-34(4)5)53(76)62-40(15)52(75)63-42(17)57(80)69(21)45(30-35(6)7)58(81)70(22)46(31-36(8)9)59(82)71(23)49(38(12)13)61(84)72(50)24/h25-26,33-46,48-51,74H,27-32H2,1-24H3,(H,62,76)(H,63,75)(H,64,78)(H,65,77)/b26-25+/t39-,40+,41+,42-,43+,44+,45+,46+,48+,49+,50+,51-/m1/s1
    InChIKey: UCOQITKXMNKTKF-MXGZYYNMSA-N
    SMILES: CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C)O

    Featured Articles

      Login

      Forgot your password?

      Don't have an account yet?
      Create account