Description
Cyclosporin D is a naturally occurring analog within the cyclosporin family of cyclic peptide compounds produced by fungi. Although closely related to Cyclosporin A, Cyclosporin D contains a different amino acid residue that alters its biological activity and its interaction with cyclophilin and calcineurin. These structural differences make Cyclosporin D a valuable research tool for investigating how subtle changes in molecular structure influence cyclosporin function.
Researchers use Cyclosporin D in comparative and structure activity relationship studies to evaluate protein binding, calcineurin inhibition, and immune signaling relative to other cyclosporin analogs. Its close structural similarity to Cyclosporin A, combined with its distinct biological properties, makes it useful for studies of cyclophilin interactions, T cell signaling, and the molecular basis of cyclosporin activity.
Cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.
Cyclosporin D is soluble in DMSO and ethyl alcohol.
Product Specifications
Cyclosporin D
Formula: C63H113N11O12
MW: 1,216.64 g/mol
Storage/Handling: Store at 4°C.
PubChem CID: 6436250
