Forskolin (Coleonol) is a labdane diterpene extracted from Coleus forskohlii (Indian Coleus plant) and is widely recognized for its potent activation of adenylate cyclase, which elevates intracellular cyclic AMP (cAMP) levels. Forskolin is ideal for use in scientific studies focused on cell signaling pathways, cAMP-mediated signal transduction, metabolic regulation, and cardiovascular research.

GoldBio’s forskolin is optimized for laboratory research and commonly used in biochemical assays investigating G protein-coupled receptor (GPCR) mechanisms, hormone signaling, and smooth muscle relaxation. Its ability to modulate cAMP makes it a valuable tool in pharmacology, molecular biology, and physiological research applications.

Applications

Activation of Adenylate Cyclase –
- Forskolin directly stimulates adenylate cyclase, increasing intracellular cAMP levels.
Investigation of GPCR Signaling –
- Forskolin is used to dissect G protein-coupled receptor (GPCR) signaling pathways by bypassing receptor activation and acting directly on adenylate cyclase.
Endocrine and Metabolic Studies –
- Forskolin is used to investigate hormone secretion, insulin signaling, lipolysis, and energy metabolism due to its modulation of cAMP.
Neuroscience and Memory Research –
- Through cAMP/PKA pathway activation, forskolin is used in studies of synaptic plasticity, long-term potentiation (LTP), and memory formation in neurological research.

Storage/Handling

Store desiccated at room temperature.

Stock Solution

100mM Forksolin Stock Solution

Dissolve 41.05 mg forskolin (mw = 410.5 g/mol) in 1 mL DMSO.
Mix thoroughly.
Store stock solution for up to 6 months at -20°C.

Catalog ID:	F-900
Source:	Coleus forskohlii
CAS #:	66575-29-9
Formula:	C₂₂H₃₄O₇
MW:	410.50 g/mol
Storage/handling:	Store desiccated at room temperature.
PubChem Chemical ID:	47936

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What is Forskolin? A Molecular Biologist’s Guide to this Powerful cAMP Modulator