Description
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Recombinant Rat Glial Cell-derived Neurotrophic Factor
GDNF
ATF1, ATF2
Astrocyte-derived Trophic Factor
Glial cell-derived neurotrophic factor (GDNF) is a small protein that promotes the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. GDNF is a founding member of the GDNF family of ligands (GFL) and has been shown to interact with GDNF family receptor alpha 1 (GDNFA1) and GDNFA2. Rat GDNF exists as a homodimer and contains seven conserved cysteine residues, one of which (Cys 101) is used for inter-chain disulfide bridging while the others are involved in intramolecular ring formation known as the cystine knot configuration.
Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.
Source: Escherichia coli
MW: ~29.8 kDa (2x 134 amino acids)
Purity: >98% by SDS-PAGE and HPLC analyses
Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 0.2 ng/ml, corresponding to a specific activity of > 5.0 × 106 IU/mg.
Storage/Handling: Store desiccated at -20°C.
RGD: 2677
NOT FOR HUMAN USE!
Additional resources for this protein may be found at:
OMIM
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