Description
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Recombinant Rat Interleukin-13
IL13
Interleukin 13
Interleukin-13 (IL13) is expressed by the IL13 gene and secreted by many cell types, especially helper T-cells type 2 (Th2). The high solution form of IL13 is reported to be a monomer with two internal disulfide bonds that contribute to a bundled four α-helix configuration. Targeted deletion of IL13 in mice resulted in impaired Th2-cell development, and indicated an important role for IL13 in the expulsion of gastrointestinal parasites. IL13 exerts anti-inflammatory effects on monocytes and macrophages and inhibits the expression of inflammatory cytokines such as IL1β, TNF-α, IL6 and IL8. IL13 has also been shown to enhance B cell proliferation, and to induce isotype switching that results in an increased production of IgE. Mature rat IL13 shares 60%, 76%, and 60% amino acid sequence identity with human, mouse, and rhesus IL13, respectively.
Sterile Filtered White Lyophilized Powder. Purified and tested for use in cell culture.
Source: Escherichia coli
MW: ~12.3 kDa (113 amino acids)
Purity: >98% by SDS-PAGE and HPLC analyses.
Storage/Handling: Store desiccated at -20°C.
NOT FOR HUMAN USE!
Rat Genome Database ID: 68949
Cross-species Homology
Percent Similarity:
| | HuIL13 | MuIL13 | RtIL13 |
| HuIL13 | *** | 57.0 | 60.2 |
| MuIL13 | *** | *** | 76.1 |
| RtIL13 | *** | *** | *** |
Additional resources for this protein may be found at:
OMIM
