Description
Minocycline HCl is a broad-spectrum tetracycline antibiotic. It has been shown to inhibit endothelial cell proliferation and angiogenesis, MMP-3, PARP, and the replication of HIV and SIV. It has also displayed anti-inflammatory and anti-collagenase activity. Minocycline HCl is freely soluble in aqueous solution.
Tetracyclines are antibiotics made up of a four-ring system. They bind the 30s ribosomal subunit, preventing the aminoacyl-tRNA from attaching to the A site. Consequently, protein synthesis is inhibited.
Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
Product Specifications
Minocycline HCl, USP Grade
Minocycline Hydrochloride
Formula: C23H27N3O7 ∙ HCl
MW: 493.94 g/mol
Storage/Handling: Store at 4°C.
PubChem Chemical ID: 54685925
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