Natamycin

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Description

Natamycin is a macrolide polyene antifungal agent isolated from Streptomyces species. It is effective against fungi such as Candida, Aspergillus, Cephalosporium, Fusarium, and Penicillium. Natamycin works by binding ergosterol and preventing carbohydrate and amino acid transport. Unlike other polyene antifungals, natamycin does not prevent ergosterol synthesis or alter cell membrane permeability. Natamycin has been used to study the lipid bilayer and as a fungicidal agent in agar media. It has also been used in research on pleiotropic regulator AdpAch. It is sparingly soluble in aqueous solution.

Natamycin is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Natamycin

MOLECULAR BIOLOGY GRADE

Formula: C33H47NO13

MW: 665.73 g/mol

Storage/Handling: Store at 2-8°C.
This product is light sensitive.

PubChem Chemical ID: 5281099

Natamycin

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Catalog Number:
N-600-50
CAS Number:
7681-93-8
$60.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
2-3 Weeks
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Natamycin is a macrolide polyene antifungal agent isolated from Streptomyces species. It is effective against fungi such as Candida, Aspergillus, Cephalosporium, Fusarium, and Penicillium. Natamycin works by binding ergosterol and preventing carbohydrate and amino acid transport. Unlike other polyene antifungals, natamycin does not prevent ergosterol synthesis or alter cell membrane permeability. Natamycin has been used to study the lipid bilayer and as a fungicidal agent in agar media. It has also been used in research on pleiotropic regulator AdpAch. It is sparingly soluble in aqueous solution.

    Natamycin is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

    Product Specifications
    Natamycin

    MOLECULAR BIOLOGY GRADE

    Formula: C33H47NO13

    MW: 665.73 g/mol

    Storage/Handling: Store at 2-8°C.
    This product is light sensitive.

    PubChem Chemical ID: 5281099

    Product Specifications

    Catalog ID: N-600
    CAS #: 7681-93-8
    Formula: C33H47NO13
    MW: 665.73 g/mol
    Grade: MOLECULAR BIOLOGY GRADE
    Storage/handling: Store at 4°C. Protect from light.
    PubChem Chemical ID: 5284447
    IUPAC Name: (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
    InChI: InChI=1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1
    InChIKey: NCXMLFZGDNKEPB-FFPOYIOWSA-N
    SMILES: CC1CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC3C(O3)C=CC(=O)O1)O)O)O)C(=O)O)OC4C(C(C(C(O4)C)O)N)O

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