Description
Nitrofurantoin is a bacteriostatic, nitrofuran antibiotic targeting gram-negative and gram-positive bacteria such as Enterococci, Staphylococci, Streptococci, Corynebacterium, and E. Coli. It has been used to study nitrofurantoin bacterial susceptibility and nitrofurantoin-induced toxicity. Additionally, it is a substrate for bacterial nitrofuran reductase.
Nitrofurantoin functions by inactivating bacterial ribosomal proteins causing inhibition of DNA, RNA, protein, and cell wall synthesis.
Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
Product Specifications
Nitrofurantoin
Formula: C8H6N4O5
MW: 238.16 g/mol
Storage/Handling: Store at 4°C. Protect from light.
Product is soluble in DMF.
NOTE: Nitrofurantoin and its solutions are discolored by alkali and by exposure to light, and are decomposed upon contact with metals other than stainless steel and aluminum.
PubChem Chemical ID: 6604200
