Description
Recombinant Human NRG1-beta1 (177-241 a.a.) contains the EGF-like domain of neuregulin 1 beta1, a signaling protein involved in the growth, differentiation, and development of multiple cell types. This biologically active region interacts with ErbB3 and ErbB4 receptor tyrosine kinases, promoting receptor dimerization with ErbB2 and activation of downstream signaling.
The defined 177-241 amino acid region makes this NRG1-beta1 protein particularly useful for research focused on ErbB receptor activation and the biological activity of the NRG1 EGF-like domain.
It can be used to study neuronal and glial cell biology, cell proliferation and differentiation, receptor signaling, synaptic biology, and other processes regulated by NRG1-ErbB interactions.
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Recombinant Human Neuregulin 1 Beta 2 (NRG1-β2)
Glial Growth Factor
Heregulin-Alpha (HRGA)
NEU Differentiation Factor (NDF)
Acetylcholine Receptor Inducing Activity
Breast Cancer Cell Differentiation Factor p45
Sensory and Motor Neuron-Derived Factor (SMDF)
Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.
Source: Escherichia coli
MW: ~7.5 kDa (65 amino acids)
Purity: >97% by SDS-PAGE and HPLC analyses
Biological Activity: Fully biologically active when compared to standard. The ED 50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 0.5 ng/ml, corresponding to a specific activity of >2.0×106 IU/mg.
Storage/Handling: Store desiccated at -20°C.
HGNC: 7997
NOT FOR HUMAN USE!
Additional resources for this protein may be found at:
OMIM
UniProt
