Description
Recombinant Human NRG1-beta2 is a neuregulin 1 isoform that contains an EGF-like signaling domain capable of activating ErbB3 and ErbB4 receptor tyrosine kinases. Through these receptor interactions and subsequent association with ErbB2, NRG1-beta2 can stimulate intracellular pathways involved in cell growth, survival, differentiation, and development.
As the beta2 form of NRG1, this recombinant protein provides you with a distinct neuregulin ligand for investigating isoform-specific activity and ErbB-mediated signaling. NRG1-beta2 is useful for studies involving epithelial, neuronal, and glial cell responses, growth factor signaling, receptor activation, and comparisons of neuregulin isoform activity.
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Recombinant Human Neuregulin 1 Beta 2 (NRG1-β2)
Glial Growth Factor
Heregulin-Alpha (HRGA)
NEU Differentiation Factor (NDF)
Acetylcholine Receptor Inducing Activity
Breast Cancer Cell Differentiation Factor p45
Sensory and Motor Neuron-Derived Factor (SMDF)
Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.
Source: Escherichia coli
MW: ~7.0 kDa (61 amino acids)
Purity: >96% by SDS-PAGE and HPLC analyses
Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 50 ng/ml, corresponding to a specific activity of >2.0×104 IU/mg.
Storage/Handling: Store desiccated at -20°C.
HGNC: 7997
NOT FOR HUMAN USE!
Additional resources for this protein may be found at:
OMIM
UniProt
