Description
Polymyxin B sulfate is a polypeptide antibiotic mixture of B1, B2, and B3 polymyxins. Each of these fractions vary by a fatty acid group and exhibit marginal MIC differences when compared. Polymyxin B is most effective against gram-negative bacteria. It has been shown to work against Pseudomonas aeruginosa, Pseudomonas viridiflava, and Erwinia carotovora. Polymyxin B is freely soluble in aqueous solution.
Polymyxin B alters membrane permeability of gram-negative bacteria, ultimately leading to cell lysis. It works by interacting with lipopolysaccharide (LPS) and does not need to enter the cell wall.
Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
Product Specifications
Polymyxin B Sulfate
solubility in H2O: soluble at 50 mg/ml
MOLECULAR BIOLOGY GRADE
Formula: C55H96N16O13 ∙ 2H2SO4
MW: 1,385.61 g/mol
Storage/Handling: Store at 2-8 °C.
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