Description
Succinylsulfathiazole — Long-Acting Sulfonamide Prodrug (Research / Antibiotic Reagent)
Product Overview
Succinylsulfathiazole (sometimes spelled succinylsulphathiazole or sulfasuccithiazole) is a sulfonamide antibiotic designed as a slow-release prodrug that primarily acts within the gastrointestinal tract. Upon hydrolysis, it releases active sulfathiazole locally, making it useful in studies of intestinal microbiota, antibiotic resistance in gut flora, and folate synthesis inhibition in bacterial systems. MedChemExpress+3Wikipedia+3goldbio.com+3
As a reagent for research use, GoldBio’s succinylsulfathiazole offers consistent purity and characterization, suitable for microbiology, pharmacology, and metabolic studies.
Key Specifications & Identity
| Property |
Value / Description |
| Synonyms / Alternate Names |
Succinylsulphathiazole; Sulfasuccithiazole; 4-oxo-4-({4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}amino)butanoic acid
|
| CAS Number |
116-43-8
|
| PubChem CID |
5315
|
| Molecular Formula |
C₁₃H₁₃N₃O₅S₂
|
| Molecular Weight |
355.39 g/mol |
| Appearance / Form |
White to off-white crystalline powder
|
| Solubility |
Very slightly soluble in water; more soluble in alkaline solutions or with heating/sonication |
| Storage / Handling |
Store sealed, at room temperature in a dry environment
|
Mechanism of Action & Biological Relevance
-
Succinylsulfathiazole acts as a prodrug: in the GI tract, it undergoes hydrolysis (mainly by bacterial or enzyme action) to yield sulfathiazole, which exerts antibacterial activity.
-
The active sulfathiazole then functions as a folate synthesis inhibitor, targeting bacterial enzymes and impairing DNA synthesis in susceptible microbes.
-
Because much of the compound remains in the intestine (≈95 % with slow absorption), it is especially useful for localized antimicrobial action in the gut with minimal systemic exposure.
Suggested Research Applications & Usage Notes
-
Gastrointestinal microbiome / antibiotic studies
Use succinylsulfathiazole to selectively suppress or perturb intestinal bacterial populations in animal or in vitro gut models, while minimizing systemic absorption.
-
Folate metabolism / nutritional modeling
As an inhibitor of folate synthesis, it may be used in bacterial or microbial culture systems to induce folate deficiency or probe metabolic responses.
-
Antibiotic resistance assays
Employ as a reference sulfonamide to test resistance mechanisms (e.g. sul genes, DHFR variants) or synergy/antagonism with other antimicrobials.
-
Prodrug / controlled release studies
Because of its slow hydrolysis and local activation, succinylsulfathiazole can be a model for prodrug design in which localized activation is desired.
Usage Tips:
-
Given its low aqueous solubility, consider preparing concentrated stocks in DMSO or alkaline buffer and then diluting into assay media with careful mixing/sonication.
-
Validate hydrolysis or activation in your system (e.g. measure conversion to sulfathiazole) before interpreting functional outcomes.
-
Use proper microbial or enzymatic controls to confirm that observed antibacterial effects derive from activated species.
-
Start with conservative doses in microbiological assays due to variability in absorption, activation, and sensitivity among strains.
Safety & Disclaimer
This product is for research use only—not for clinical, diagnostic, or therapeutic applications.
Handle with standard laboratory safety procedures: use gloves, eye protection, and work in well-ventilated or contained conditions. Avoid inhalation, ingestion, or skin contact.
Dispose of waste and residual material in compliance with institutional and regulatory guidelines for antibiotic / chemical disposal.
