Description
Recombinant Human TNF-α (His) combines the biological properties of TNF-α with an N-terminal 6x-His tag that facilitates affinity-based purification, detection, and experimental manipulation.
TNF-α is a pro-inflammatory cytokine that interacts with TNFR1 and TNFR2 to regulate signaling associated with inflammation, immune responses, cell survival, and apoptosis.
The 6x-His tag makes this recombinant protein particularly useful for experiments requiring immobilization, pull-down studies, affinity purification, or detection with His-tag-specific reagents.
Produced in E. coli and purified to greater than 97%, TNF-α (His) provides researchers with a tagged alternative to unmodified recombinant Human TNF-α for protein interaction and receptor signaling studies.
TNF-α, His has an identical amino acid sequence to Human TNF-α, but with 6x-His at the N-terminus for protein purification (see Additional Information for sequence).
Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.
Similarity
|
HuTNF |
MuTNF |
| HuTNF |
*** |
79.1 |
| MuTNF |
*** |
*** |
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Recombinant Human Tumor Necrosis Factor, His
TNF-α, TNF-alpha
Cachectin, Cachexin
Source: Escherichia coli
MW: ~18.3 kDa (157 amino acid plus 6x His at N-terminus)
Purity: >97% by SDS-PAGE and HPLC analyses
Storage/Handling: Store desiccated at -20°C.
NOT FOR HUMAN USE!
HGNC:11892
Cross-species homology
Percent Additional resources for this protein may be found at:
OMIM
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