Description
Tropine — Tropane Building-Block & Alkaloid Intermediate
Product Overview
Tropine (CAS 120-29-6) is a bicyclic tropane alkaloid derivative that serves as a central scaffold in the biosynthesis and synthesis of biologically active natural products (e.g. atropine, scopolamine).
As a research reagent, Tropine is prized as a chemical intermediate, synthetic precursor, and model compound in alkaloid chemistry, neuropharmacology, and natural product synthesis.
Key Specifications & Identity
| Property |
Value / Description |
| Synonyms / Alternate Names |
3-Tropanol; α-Tropine |
| CAS Number |
120-29-6
|
| PubChem CID |
8424
|
| Molecular Formula |
C₈H₁₅NO
|
| Molecular Weight |
~141.21 g/mol
|
| Appearance |
White to slightly yellow, hygroscopic crystalline powder or plates
|
| Solubility |
Very soluble in water, diethyl ether, ethanol
|
| Stability / Handling |
Hygroscopic; protect from moisture and store sealed
|
Functional Features & Applications
-
Synthetic intermediate — Tropine is a key building block in the synthesis of tropane alkaloids (e.g. atropine, scopolamine) and synthetic analogs thereof.
-
Model in neuropharmacology / structure-activity studies — Because tropine is the core tropane unit, it is useful in designing derivatives or probing structure–function relationships of muscarinic antagonists.
-
Biochemistry / enzyme studies — Enzymes such as tropinone reductase convert tropine ↔ tropinone in alkaloid biosynthesis pathways.
Usage Notes & Tips
-
Prepare fresh solutions (e.g. in water or ethanol) and protect from moisture / light to maintain integrity.
-
Because tropine is hygroscopic, ensure minimal exposure to ambient humidity when handling or weighing.
-
Validate compatibility of solvents and conditions, particularly for downstream transformations or coupling reactions.
-
Always consult the Certificate of Analysis (COA) for batch-specific purity and handling guidelines.
Safety & Disclaimer
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For research / laboratory use only. Not for human or veterinary use.
-
Tropine is classified as harmful if swallowed or inhaled (GHS hazard) and an irritant.
-
Use appropriate personal protective equipment (gloves, goggles, lab coat) and handle in a fume hood or well-ventilated area.
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Avoid exposure via inhalation or ingestion. In case of contact, follow first aid measures in the SDS.
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Dispose of unused material and waste according to institutional and regulatory chemical disposal protocols.
