Description
Vancomycin Hydrochloride, USP Grade — Glycopeptide Antibiotic for Research & Selection Applications
Product Overview
Vancomycin Hydrochloride is a high-purity glycopeptide antibiotic derived from Streptomyces orientalis. In research settings, USP-grade vancomycin is widely used as a selective agent in microbiology, to study antibiotic resistance mechanisms, and in controlled culture systems (including plant or mammalian cell culture) to suppress Gram-positive bacterial contamination. GoldBio’s USP grade vancomycin offers reliable potency, compliance with pharmacopeial standards, and documentation (e.g. Certificate of Analysis).
TESTED AGAINST BOTH SENSITIVE AND RESISTANT CELLS AT GOLD BIOTECHNOLOGY LAB.
Key Specifications & Identity
| Property |
Value / Description |
| Synonyms / Alternate Names |
Vancomycin HCl; Vancomycin Hydrochloride |
| CAS Number |
1404-93-9
|
| PubChem CID |
14970
|
| Molecular Formula |
C₆₆H₇₅Cl₂N₉O₂₄ · HCl (salt form)
|
| Molecular Weight |
1,485.71 g/mol (including HCl)
|
| Potency |
> 1,000 µg vancomycin equivalent per mg (on anhydrous basis)
|
| Solubility |
Soluble in water
|
| Storage & Handling |
Store desiccated at –20 °C, protected from moisture and light
|
Mode of Action & Biological Relevance
-
Vancomycin is an antibiotic whose primary mode of action is inhibition of bacterial cell wall synthesis. Specifically, it binds to the D-Ala–D-Ala terminal residues of peptidoglycan precursors, preventing polymerization and cross-linking.
-
Because it targets Gram-positive cell wall pathways, vancomycin is particularly effective against Gram-positive bacteria (e.g. Staphylococcus spp., Enterococcus spp.).
-
In research settings, it is often used at selective concentrations to suppress unwanted Gram-positive bacterial growth in mixed cultures or to apply selective pressure in antibiotic resistance studies.
Suggested Applications & Usage Notes
-
Selective media / contamination control
Incorporate vancomycin into culture media (bacterial, plant, mammalian) to suppress Gram-positive contaminants while allowing growth of desired organisms.
-
Antibiotic resistance / susceptibility assays
Use as a reference antibiotic in MIC (minimum inhibitory concentration) testing, resistance screening, or mechanistic studies.
-
Combination / synergy experiments
Combine with other antibiotics (e.g. β-lactams, aminoglycosides) to investigate synergistic or antagonistic interactions in bacterial systems.
-
Modeling resistance evolution / genetic studies
Apply vancomycin stress in evolutionary experiments or to select for resistant mutants for downstream genomic/phenotypic analysis.
Usage Tips:
-
Always validate effective concentration for your specific organism/culture system; vancomycin’s effective range depends on strain sensitivity.
-
Solubilize fresh stocks in sterile water; filter-sterilize if necessary.
-
Use matched vehicle or salt controls to account for ionic / osmotic effects.
-
Refer to the Certificate of Analysis (COA) to confirm potency and lot-specific data before use.
Safety & Disclaimer
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For research use only. Not for human or veterinary use.
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Vancomycin can be hazardous; handle in compliance with institutional safety protocols (PPE, containment, fume hood).
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Avoid inhalation, ingestion, or contact with skin/eyes.
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Dispose of waste and unused material in accordance with institutional and regulatory guidelines for antibiotics and chemical agents.
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