The primary attribute of DDM is its capability to extract hydrophobic proteins while maintaining the solution-phase protein conformation. DDM also allows the protein to be reformed following denaturization. Most membrane-bound proteins are α-helix bundles, which are less robust to changes in their cellular environment. DDM offers a detergent capable of preserving these proteins. This is in contrast to other, harsher ionic detergents that destabilize and permanently denature α-helical membrane-bound proteins. DDM has been used to solubilize the multidrug-transporter protein, EmrE, as well as the nucleoside-specific porin protein, Tsx.

Octylglucoside is a nonionic, mild detergent used to isolate membrane proteins in the native state. It can easily be removed during final extractions by dialysis.

Characteristics that contribute to this detergent’s usefulness are its water solubility, chemical structure and small-sized micelles.

Octylglucoside also provides higher resolution of proteins in 2D electrophoresis.

Octylthioglucoside is a nonionic detergent that has been used to isolate membrane proteins without inactivation. This product is effective in a variety of protein solubilization and cell lysis processes. And detergents of this nature are ideal when studying the conformation and structure of proteins because the secondary and tertiary structures remain intact.

Compared to octylglucoside, octylthioglycoside is more stable. And it is stable in aqueous solution and easily removed by dialysis. This product is intended for use as a detergent to solubilize membrane-bound proteins in their native state.

Tridecyl b-D-maltopyranoside is a disaccharide derivative and glycoside which is applied as a non-ionic detergent and surfactant. In studies on membrane protein crystallization, Tridecyl b-D-maltopyranoside proved to be an effective detergent for maintaining protein solubility but necessitates the presence of salt. Tridecyl b-D-maltopyranoside has a longer chain length than Decyl β-D-maltopyranoside, another detergent used on membrane protein crystallization. Decyl β-D-maltopyranoside has been used in micellar electrokinetic chromatography to study enantiomer separation of drugs.