SAA1 is a positive acute phase apolipoprotein reactant that associates with HDL. It is expressed predominantly by hepatocytes in the liver and secreted into plasma, but is also expressed and secreted by adipocytes, endothelial cells, and peripheral monocytes. Expression of SAA1 is induced by LPS and by a variety of cytokines such as IL1, IL6, and TNF. Induction causes a dramatic increase of SAA1 levels in blood, indicating that it may play a short-term role in response to injury and inflammation. SAA1 can aggregate into insoluble fibrils that are deposited in various tissues or organs and disrupt normal function, a condition known as amyloidosis. Amyloidosis of SAA1 is associated with rheumatoid arthritis. SAA1 induces the synthesis of a variety of cytokines and proteinases and inhibits proliferation of endothelial cells. When not bound to HDL, it is chemotactic for monocytes, phagocytes, CD4(+) and CD8(+) T-cells, and polymorphonuclear leukocytes. SAA1 is a ligand for CD36/SR-B3, SR-B1, FPRL1, TLR2, and RAGE.

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

GoldBio Safe-Soap (also called SequeSoap) is used to clean the glass plates that are commonly used for acrylamide gels!

You demand crisp bands on your gels. But repeated use of glass plates for gels leaves behind carbonate and silicate residue, chemical deposits and microscopic scratches on plate surfaces that can lead to tears in the gel when separating the plates following the run.

Salinomycin is a coccidiostat ionophore antibiotic isolated from Streptomyces albus. It increases cation movement across cell membranes through exchange-diffusion, resulting in altered gradients due to a lack of control of ion permeability. This effect allows ions (K+, Na+, Ca+, Mg2+) to accumulate inside the cell, reaching toxic levels.

Salinomycin is a coccidiostat ionophore antibiotic isolated from Streptomyces albus. It increases cation movement across cell membranes through exchange-diffusion, resulting in altered gradients due to a lack of control of ion permeability. This effect allows ions (K+, Na+, Ca+, Mg2+) to accumulate inside the cell, reaching toxic levels. Salinomycin sodium is freely soluble in aqueous solution.

Salmon Gal (6-Chloro-3-indolyl-β-D-galactopyranoside) is used with IPTG as an alternative chromogenic substrate capable of detecting LacZ gene encoded ß-galactosidase activity for colony screening in colometric assays.

Unlike colony blue/white screening through X-Gal, nonrecombination results in a salmon color after salmon gal is cleaved by ß-galactosidase through hydrolysis. This contrast may be useful in comparative or secondary screenings.

Incorporating nitroblue tetrazolium salt (NBT) into the salmon gal reactions provides faster results with a clear, purple precipitate than in unaccompanied uses of salmon gal.

Sarafloxacin is a broad-spectrum fluoroquinolone antibiotic effective against a variety of gram-negative and gram-positive organisms, especially Mycobacterium tuberculosis. Sarafloxacin HCl Trihydrate is water soluble.

The distance between the handle and the blade of this scalpel (18 cm) has been lengthened to reduce the risk of contamination. The handle’s low weight and ergonomic shape makes this a handy tool for cutting plantlets.

Semicarbazide HCl is a reagent used to produce aldehyde and ketone derivatives. These derivatives are crystalline compounds with specific melting points. Semicarbazide HCl is a nitrofuran metabolite.

Serpin Peptidase Inhibitory, clade F (SERPINF1), previously called Pigment epithelium-derived factor (PEDF), is encoded by the SERPINF1 gene in humans and found in vertebrates. It is a secreted phosphoglycoprotein that belongs to the clade F subfamily, serpin superfamily of proteinase inhibitors. SERPINF1 is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is synthesized as a 418 amino acid, ~50 kDa precursor that contains a 19 amino acid signal sequence and a 399 amino acid mature region that shows a pyroglutamate at Gln20. Like other serpins, it contains three β-sheets, 810 α-helices, and a C-terminal RCL (reactive center loop). Unlike other serpins with Ser protease inhibiting activity, SERPINF1 has induces extensive neuronal differentiation in retinoblastoma cells, inhibiting of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. SERPINF1 is researched as a therapeutic candidate for treatment of such conditions as choroidal neovascularization, heart disease, and cancer.