Members of the Hedgehog (Hh) family are highly conserved proteins that are widely represented throughout the animal kingdom. The three known mammalian Hh proteins, Sonic (Shh), Desert (Dhh) and Indian (Ihh), are structurally related and share a high degree of amino acid sequence identity. Each Hh protein has a unique expression pattern and distinct biological role within its respective region of secretion. All Hh proteins use the same signaling pathway and can substitute for each other in experimental systems. Shh has been found to have a critical role in development, acting as a morphogen in the patterning of limbs, brain structure, spinal cord, thalamus and the teeth. Shh has been shown to attract commissural axons in the developing spinal cord by attracting or repelling retinal ganglion cell (RGC) axons depending on concentration.

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Murine Sonic HedgeHog (SHH) rMuSHH Hhg1 Hxl3

Members of the Hedgehog (Hh) family are highly conserved proteins that are widely represented throughout the animal kingdom. The three known mammalian Hh proteins, Sonic (Shh), Desert (Dhh) and Indian (Ihh), are structurally related and share a high degree of amino acid sequence identity. Each Hh protein has a unique expression pattern and distinct biological role within its respective region of secretion. All Hh proteins use the same signaling pathway and can substitute for each other in experimental systems. Shh has been found to have a critical role in development, acting as a morphogen in the patterning of limbs, brain structure, facial structure, lungs, spinal cord, thalamus and the teeth. Shh has been shown to attract commissural axons in the developing spinal cord by attracting or repelling retinal ganglion cell (RGC) axons depending on concentration. Murine SHH is frequently coexpressed with BMP2, BMP4, and BMP6.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

Simple Stop™ 1 is a broad-spectrum phosphatase inhibitor cocktail consisting of five phosphatase inhibitors in two solutions that target all the phosphatase categories: serine/threonine (Ser/Thr) specific phosphatase, tyrosine specific phosphatase, dual specificity phosphatases, acid phosphatase and alkaline phosphatase.

Each Simple Stop™ phosphatase inhibitor cocktail solution is a 100X concentrated, ready-to-use, solution. Simply add cocktail solution “A” and cocktail solution “B” to your extraction buffers or samples and you are ready to go. This cocktail is ideal for inhibition in tissue extractions and cell lysis experiments and is compatible with most common protein assays.

Simple Stop™ 2 is a broad-spectrum phosphatase inhibitor cocktail consisting of five phosphatase inhibitors in two solutions that target all the phosphatase categories: serine/threonine (Ser/Thr) specific phosphatase, tyrosine specific phosphatase, dual specificity phosphatases, acid phosphatase and alkaline phosphatase.

Each Simple Stop™ phosphatase inhibitor cocktail solution is a 100X concentrated, ready-to-use, solution. Simply add cocktail solution “A” and cocktail solution “B” to your extraction buffers or samples and you are ready to go. This cocktail is ideal for inhibition in tissue extractions and cell lysis experiments and is compatible with most common protein assays.

Simple StopTM 3 is a phosphatase inhibitor cocktail consisting of three phosphatase inhibitors that target alkaline and serine/threonine phosphatases. It is a stabilized solution of cantharidin, bromotetramisole and microcystin LR. It is compatible with IEF/2D studies.

The Simple StopTM phosphatase inhibitor cocktails are 100X concentrated, ready-to-use solutions that are simply added to your extraction buffers or samples. They are ideal for inhibition in tissue extractions and cell lysis experiments and are compatible with most common protein assays.

Sincalide is an octapeptide hormone in the intestine and brain. When secreted it causes the release of bile from the gallbladder and digestive enzymes from the pancreas. It forms the C-terminal fragment of cholecystokinin or CCK-8.

Sisomicin is a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. It is related to gentamicin and targets gram-negative and gram-positive bacteria such as Klebsiella species, E. coli, P. aeruginosa, Enterobacter species, and Proteus species. It has been used in disk and tube dilution sensitivity assays.

Sodium 3-hydroxybutyrate is a biochemical used in proteomics research.

Sodium glucuronate is a sugar derived carboxylic acid involved in glucuronidation, where glucuronic acid is bonded to a molecule, which allows for transport since glucuronate is highly water-soluble. This allows for the delivery of drugs or the removal of toxins from cells. It is used to increase cell toxin removal and to increase drug or hormone delivery to cells. and is one of the precursors to vitamin C.

Sodium orthovanadate is a general competitive inhibitor of tyrosine specific phosphatases, acid and alkaline phosphatases and ATPases. Phosphatase inhibition from Vanadate may be completely reversed by dilution or by the addition of EDTA.

Sodium polyanetholesulfonate (SPS) is a homopolymer that was developed to be used as an anticoagulant. It is commonly used in blood culture media for bacteria because it inhibits the antimicrobial activity of immune system components present in blood. SPS inhibits the growth of some microorganisms, but this effect if often media-dependent and can be overcome by addition of gelatin or lysed blood. SPS is a weaker anticoagulant than heparin, most likely due to inhibition of antithrombin III, but a stronger inducer of platelet aggregation. It has also been used to stabilize colloidal suspensions.