Amoxicillin/Clavulanate combines an extended-spectrum β-lactam antibiotic with a β-lactamase inhibitor. Amoxicillin is an extended-spectrum ß-lactam antibiotic with a structure similar to that of ampicillin. It is effective against a variety of ß-lactamase negative bacteria including E. coli and various Streptococcus and Staphylococcus bacteria; however, when combined with clavulanic acid, ß-lactamase enzymes are irreversibly inactivated. Consequently, amoxicillin/clavulanate is effective against ß-lactamase-negative and ß-lactamase-positive bacteria.

Clavulanic acid potassium (clavulanate potassium) is a β-lactamase inhibitor isolated from Streptomyces clavuligerus, which irreversibly inactivates β-lactamase enzymes of β-lactam resistant organisms. This prevents these organisms from degrading β-lactam antibiotics. Clavulanic acid can be combined with antibiotics to increase their potency and is often combined with amoxicillin.

Clavulanic acid, lithium salt or lithium clavulanate is an irreversible inhibitor of β-lactamase class A enzymes, which target β-lactam antibiotics. Clavulanic acid, lithium salt has been shown operate more efficiently with ceftazidime and amoxicillin antibiotics. Research has also shown an increase in AmpC β-lactamase expression when lithium clavulanate was administered in vitro to Enterobacteriaceae.

Clavulanic acid, lithium salt potentiates antibiotic effects of penicillin binding protein (PBP) inhibitors by preventing their deconstruction. Effective inhibition of β-lactamases by this compound expand antibiotic duration and lethality, making it useful for susceptibility tests or bacterial selection.

Sulbactam is a β-lactamase inhibitor useful in combination with β-lactam antibiotics to increase their potency. It irreversibly inactivates β-lactamase enzymes, preventing them from degrading β-lactam antibiotics. Sulbactam has been used in combination with ampicillin and cefoperazone to inhibit β-lactamase enzymes during Agrobacterium-mediated plant genetic modifications. It may also be used in cell signaling studies.

Sulbactam is a β-lactamase inhibitor useful in combination with β-lactam antibiotics to increase their potency. It irreversibly inactivates β-lactamase enzymes, preventing them from degrading β-lactam antibiotics. Sulbactam has been used in combination with ampicillin and cefoperazone to inhibit β-lactamase enzymes during Agrobacterium-mediated plant genetic modifications. It may also be used in cell signaling studies. Sulbactam sodium is freely soluble in aqueous solution.

Tazobactam is a β-lactamase inhibitor useful in combination with β-lactam antibiotics to increase their potency. It irreversibly inactivates β-lactamase enzymes, preventing them from degrading β-lactam antibiotics. Tazobactam has been used in combination with piperacillin and a variety of other antibiotics. Tazobactam is less soluble in aqueous solution than tazobactam sodium.

Tazobactam is a β-lactamase inhibitor derived from penicillin. It is used along with β-lactam antibiotics, to prevent their degradation by β-lactamase enzymes. Tazobactam is often used with piperacillin to increase its potency. Additionally, tazobactam is used in studies regarding β-lactamase and penicillinase inhibition.