The 3xERRE-luciferase plasmid is designed to study the activity of the Estrogen-Related Receptor (ERR) signaling pathway, specifically its role in transcriptional regulation. This plasmid contains three copies of the Estrogen-Related Receptor Response Element (ERRE), which is a DNA sequence recognized by the estrogen-related receptor (ERR) family of transcription factors. ERK/MAPK regulates ERRgamma expression, transcriptional activity, and receptor-mediated Tamoxifen resistance in ER+ breast cancer.

The 3xERRE-luciferase plasmid is a synthetic plasmid obtained from a third party and its sequence has been confirmed at GoldBio

The 4xCSL-luciferase plasmid is designed to study the Notch signaling pathway by monitoring the transcriptional activity of CSL (CBF1/Suppressor of Hairless/LAG-1), a key transcription factor in the Notch pathway.

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.

The 4xCSL-luciferase plasmid is a synthetic plasmid obtained from a third party and its sequence has been confirmed at Goldbio.

The HRE-luciferase plasmid is designed for use in studies related to hypoxia (low oxygen) or oxygen-regulated gene expression. It contains a Hypoxia Response Element (HRE) upstream of a luciferase reporter gene. PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).

The HRE-Luciferase plasmid is a synthetic plasmid obtained from a third party and its sequence has been confirmed at GoldBio.

The Lenti-luciferase-P2A-Neo plasmid is a lentiviral vector designed for gene expression studies, particularly in mammalian cells, using luciferase as a reporter gene. The plasmid includes a P2A self-cleaving peptide and Neomycin resistance gene (Neo), which allow for both the expression of luciferase and the selection of successfully transduced cells. The lentiviral backbone ensures stable integration into the host genome, making it useful for long-term studies.

A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia.

The pLenti-luciferase-P2A-Neo plasmid is a synthetic plasmid obtained from a third party and its sequence has been confirmed at GoldBio.

The pMicroRNA studies Luciferase plasmid is specifically designed for studying the regulation of gene expression by microRNAs (miRNAs) and other post-transcriptional regulatory factors. The plasmid contains a luciferase reporter gene that can be fused to the 3′ untranslated region (3′ UTR) of a target gene, allowing researchers to investigate how miRNAs or RNA-binding proteins influence the stability and translation of mRNA.

The pMicroRNA studies Luciferase plasmid is a synthetic plasmid obtained from a third party and its sequence has been confirmed at GoldBio.

The MSCV IRES Luciferase plasmid is designed to facilitate the study of gene expression and the regulation of specific genes in various biological contexts, particularly in hematopoietic cells (blood cells) and stem cell research. This plasmid incorporates a murine stem cell virus (MSCV) backbone, an internal ribosome entry site (IRES), and a luciferase reporter gene.

The pMSCV IRES Luciferase plasmid is a synthetic plasmid obtained from a third party and its sequence has been confirmed at GoldBio.

The pGL3 BRE Luciferase plasmid is designed to study the activity of the BMP (Bone Morphogenetic Protein) signaling pathway by monitoring transcriptional responses to BMP signaling. The BRE (BMP Response Element) in this plasmid is a specific DNA sequence that is activated by the BMP pathway's SMAD transcription factors.

The pGL3 BRE Luciferase plasmid is a synthetic plasmid obtained from a third party and its sequence has been confirmed at GoldBio.

The pGL3-RARE-luciferase plasmid is designed to study the activity of the retinoic acid (RA) signaling pathway, specifically focusing on transcriptional regulation through Retinoic Acid Response Elements (RAREs). This plasmid is used to monitor the transcriptional activity that is mediated by the binding of retinoic acid receptors (RARs) to RAREs in response to retinoic acid, a derivative of vitamin A that plays critical roles in cell differentiation, development, and metabolism.

The pGL3-RARE Luciferase plasmid is a synthetic plasmid obtained from a third party and its sequence has been confirmed at GoldBio.

The pIRES-Luciferase-hRluc plasmid is designed to study gene expression, regulation, and co-expression of two reporter genes, firefly luciferase and Renilla luciferase, from a single mRNA transcript. This plasmid includes an Internal Ribosome Entry Site (IRES) that allows the simultaneous expression of both reporter genes, providing a powerful tool for studying transcriptional and translational regulation.

The pIRES-Luciferase-hRluc plasmid is a synthetic plasmid obtained from a third party and its sequence has been confirmed at GoldBio.

The TFEB promoter-luciferase reporter plasmid is designed to study the transcriptional regulation of the TFEB (Transcription Factor EB) gene, a master regulator of autophagy and lysosomal biogenesis. By linking the TFEB promoter to a luciferase reporter gene, researchers can assess how different factors influence the transcriptional activity of the TFEB promoter, and thus, how TFEB expression is regulated under various conditions.

PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.

The pTFEB promoter-luciferase reporter plasmid is a synthetic plasmid obtained from a third party and its sequence has been confirmed at GoldBio.