5-Bromo-4-chloro-3-indoxyl-1-acetate is a histochemical substrate for esterase.

5-Bromo-4-chloro-3-indoxyl-3-acetate is a histochemical substrate for esterase.

5-Bromoindole is a heterocyclic building block and a potential GSK-3 inhibitor.

5-Bromoindole is used as a reagent for chemical synthesis. When reacted with 3-acetic acid it can be used with horseradish peroxidase to characterize in vivo for cancer gene therapy.

5-Bromoindole-2-carboxylic acid is a heterocyclic building block used to synthesize a variety of biochemical compounds. It was used in the discovery of indole inhibitors of MMP-13 and the synthesis of indolyl ethanones useful as indoleamine 2,3-dioxygenase inhibitors. Additionally, 5-Bromoindole-2-carboxylic acid is used to synthesize cis-diaminocyclohexane derivatives useful as Xa inhibitors as well as tubulin polymerization inhibitors and anticancer agents.

5-Chloroindole is researched for its use as an antidepressant, antiemetic, and anti-parkinson agent. It is useful in the synthesis of 5-chloro-tryptamine, which is an intermediate involved in the preparation of antihypertensive agents and tranquilizers.

5-Hydroxyindole is a reagent useful for a variety of preparation procedures, including: preparation of 5-vinyl-3-pyricindecarbonitrices as PKCϴ inhibitors, melanins, indole dopamine D2 receptor antagonists, anthranilic acids, anticancer agents, and tubulin inhibitors.

5-Hydroxyindole-2-carboxylic acid is used in a variety of preparation procedures, including: preparation of oxadiazole analogs as SH2 inhibitors of tyrosine kinase ZAP-70, peptidomimetic inhibitors of signal transducers and Stat3 activators, 5-hydroxyindole-2-carboxylic acid amides as histamine-3 receptor inverse agonists, melanins, and anticancer agents. Upon oxidation with KMnO4, 5-hydroxyindole-2-carboxylic acid yields pyrrole-2,3,5-tricarboxylic acid.

5-Hydroxyindole-3-acetic acid is the primary serotonin metabolite and a biomarker researched for its implication in intestinal carcinoid syndrome. Additionally, 5-HIAA has been shown to be increased in diseases such as Celiac disease and Whipple disease.