Baicalin is a flavone glycoside formed from the glucuronidation of baicalein. It has an array of properties which include promoting cell survival and bolstering the immune system. One of the effects that baicalin produced with in vitro studies of pathogens and in vivo studies on rats and mice was an elevation in cell survival, which implied the prevention of cell death due to induced apoptosis or the accumulation of oxidative species. Apoptotic repression occurred in rats due to a decreased expression of proteins within the CHOP (C/EBP homologous protein) pathway. Stimulating the synthesis of endothelial nitrogen oxides (eNOS) and other nitrogen oxides quell oxidative stress with the termination of free radicals.

Additionally, protective effects of baicalin have specifically diminished injury in the hippocampal area. Baicalin has been shown to stimulate the expression of Bcl-2 (B-cell lymphoma-2) which regulates apoptosis. It has also been shown to decrease miR-497 expression and cleave caspase-3 protein synthesis. These play roles in regulating gene expression and nervous system cell apoptosis respectively.

Enhancing the immune response with baicalin has proven effective in two ways. One observed effect was the induction of IFN-γ cytokine production in mice, a cytokine which activates macrophages and MHC II (major histocompatibility complex II) expression. Lysozyme bacteriostatic duration was shown to increase when exposed to increasing concentrations of baicalin.

FGF2 is a member of the fibroblast growth factor family of proteins. It is often called FGF-basic or bFGF. FGF2 is a single-chain polypeptide growth factor that plays a significant role in wound healing, it is a potent inducer of angiogenesis and it is essential for the growth of many stem and progenitor cells. FGF2 shares a 55% amino acid residue identity with FGF1 and interacts with heparin sulfate with nanomolar affinity. It is a potent inducer of DNA synthesis in a variety of cell types. FGF2 activates mesenchymal splice variants of FGF receptors (c splice variants) and also activates FGF Receptor 1b, but has little activity against FGFR2b or FGFR3b. It is most closely associated with FGF1 (aFGF) (see additional information).

FGF2 is a member of the fibroblast growth factor family of proteins. It is often called FGF-basic or bFGF. FGF2 is a single-chain polypeptide growth factor that plays a significant role in wound healing, it is a potent inducer of angiogenesis and it is essential for the growth of many stem and progenitor cells. FGF2 shares a 55% amino acid residue identity with FGF1 and interacts with heparin sulfate with nanomolar affinity. It is a potent inducer of DNA synthesis in a variety of cell types. FGF2 activates mesenchymal splice variants of FGF receptors (c splice variants) and also activates FGF Receptor 1b, but has little activity against FGFR2b or FGFR3b. It is most closely associated with FGF1 (aFGF).

FGF2 is a member of the Fibroblast Growth Factor family of proteins. It is often called FGF-basic or bFGF. FGF2 is a single-chain polypeptide growth factor that plays a significant role in wound healing, it is a potent inducer of angiogenesis and it is essential for the growth of many stem and progenitor cells. FGF2 shares a 55% amino acid residue identity with FGF1 and interacts with heparin sulfate with nanomolar affinity. It is a potent inducer of DNA synthesis in a variety of cell types. FGF2 activates mesenchymal splice variants of FGF receptors (c splice variants) and also activates FGF Receptor 1b, but has little activity against FGFR2b or FGFR3b. It is most closely associated with FGF1 (aFGF) (see additional information).

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Rat Fibroblast Growth Factor 2Fibroblast Growth Factor-basicbFGF, FGF-2basic FGF

FGF2 is a member of the Fibroblast Growth Factor family of proteins. It is often called FGF-basic or bFGF. FGF2 is a single-chain polypeptide growth factor that plays a significant role in wound healing, it is a potent inducer of angiogenesis and it is essential for the growth of many stem and progenitor cells. FGF2 shares a 55% amino acid residue identity with FGF1 and interacts with heparin sulfate with nanomolar affinity. It is a potent inducer of DNA synthesis in a variety of cell types. FGF2 activates mesenchymal splice variants of FGF receptors (c splice variants) and also activates FGF Receptor 1b, but has little activity against FGFR2b or FGFR3b. It is most closely associated with FGF1 (aFGF) (see additional information).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

BCIP is a white to off-white powder that is used as a substrate for visualization of alkaline phosphatase. The end product is insoluble and purple when used with nitroblue tetrazolium. This final product can be visually detected. BCIP is DMF soluble.

Benzalkonium chloride is a cationic detergent and member of the quaternary ammonium compounds. It is studied for its effect on epithelial conjunctival cells in vitro.

Benzamidine hydrochloride monohydrate is an aromatic amidine. It is used in protein extractions as a strong reversible inhibitor of serine proteases such as trypsin, thrombin, plasmin and other trypsin-like proteases. Compared to aprotinin, benzamidine is considered to be just as effective in preventing the degradation of glucogon.

Bergapten or 5-Methoxypsoralen is a linear 5-methoxyfurocoumarin with photosensitizing effects occurring as a natural metabolite in plants like anise and celery. Concentrated amounts are found in bergamot and other citrus essential oils, causing phototoxicity. Its photochemical properties have led to application as a photonic material, heptatoprotective agent and skin pharmaceutical. It manifests as a crystalline solid and is stable, combustible and incompatible with strong oxidizing agents.

Bergapten has been studied as an antitumor agent in cancer research. In combination with UV light irradiation, Bergapten has been used to manage diseases like psoriasis and vitiligo and can also inhibit hepatocellular carcinoma cell proliferation. As a selective potassium-channel blocker, it reduces K-permeability at nodes of Ranvier, possibly producing fasciculation and cramps. Exposure to the corrosive chemical has demonstrated negative effects on health including erythema, dermatitis, hyperpigmentation and epitheliomas.

BES is a zwitterionic buffering agent used in biochemistry and molecular biology that was first selected and described by Good et al. It is a bis(2-hydroxyethyl)amine buffer that is useful for a pH range of 6.4 – 7.8. It is soluble in water at 0°C up to 3.2M. Like most neutral, amine-based buffers, BES forms a complex with DNA. It interferes with reactions between DNA and restriction enzymes to a lesser extent than similar buffers with less substituted amine groups, such as Tris. This lack of interference occurs because steric hindrance of the protonated tertiary amine in BES shields the negative charge of DNA to a lesser extent than less substituted buffers. BES can be used in a buffered saline solution in the calcium phosphate mediated transfection of eukaryotic cells with plasmid DNA. BES also forms a complex with certain metals, including copper and cobalt. Though BES binds to coppers ions, it is still suitable for use with the bicinchoninic acid (BCA) assay. Diminished protein-induced color development can be accounted for or even eliminated by precipitating protein prior to reaction with bicinchoninic acid.