CCL20 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed in the liver as well as in lymphocytes, monocytes, and leukemia cells that have been induced by a mediator of inflammation, such as IFNG, IL1B, LPS, or PMA. It is upregulated in psoriasis because of proinflammatory mediators produced in the skin and attracts T lymphocytes to lesions. CCL20 is chemotactic mainly for lymphocytes, but also for granulocytes and immature dendritic cells. It is a ligand for CCR6.

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CCL20 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed in the liver as well as in lymphocytes, monocytes, and leukemia cells that have been induced by a mediator of inflammation, such as IFNG, IL1B, LPS, or PMA. It is upregulated in psoriasis because of proinflammatory mediators produced in the skin and attracts T lymphocytes to lesions. CCL20 is chemotactic mainly for lymphocytes, but also for granulocytes and immature dendritic cells and it plays a role in development of mucosal lymphoid tissue. It is a ligand for CCR6.

CCL21 is a chemokine containing six conserved cysteine residues, two of which are adjacent. It is expressed in high endothelial venules of lymph nodes, as well as tonsils, breast stromal cells, and a variety of other cells. Expression of CCL21 is inhibited by IFNG. It is chemotactic for peripheral blood lymphocytes and plays a major role in initiation and expansion of adaptive immune responses, as well as development of local lymphoid tissue. CCL21 is a ligand for CCR7, as well as CXCR3 and the virorecptor M3.

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CCL21 is a chemokine containing six conserved cysteine residues, two of which are adjacent. Murine CCL21 is encoded by two to three genes, depending on the strain, each product of which differs by a single amino acid and expression of these genes is regulated differentially. It is expressed in high endothelial venules of lymph nodes, as well as lung, spleen, tonsils, breast stromal cells, and a variety of other cells. Murine CCL21-Leu is expressed predominantly in the lung independent of an inducer. Expression of CCL21 is inhibited by IFNG. It is chemotactic for peripheral blood lymphocytes and plays a major role in initiation and expansion of adaptive immune responses, as well as development of local lymphoid tissue. CCL21 is a ligand for CCR7, as well as CXCR3 and the virorecptor M3.

CCL22 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed in thymus tissue, macrophages, and dendritic cells. Expression of CCL22 is induced by IL4 and IL13 and inhibited by IL10. It is chemotactic for chronically activated T cells and plays a role in trafficking activated T cells. It also plays a role in migration and survival of cells expressing FOXP3 in HTLV1 infection. CCL22 is a ligand for CCR4.

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Murine CCL22 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed in activated splenic B-cells, macrophages, and dendritic cells. Expression of CCL22 is induced by IL4 and IL13 and inhibited by IL10. Increased expression of murine CCL22 has also been observed from bone marrow-derived mast cells after incubation with TNF-alpha or IgE. CCL22 is chemotactic for chronically activated T-cells and plays a role in trafficking activated T cells. It also plays a role in migration and survival of cells expressing FOXP3 in HTLV1 infection. CCL22 is a ligand for CCR4.

Rat CCL22 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed in activated splenic B-cells, macrophages, and dendritic cells. Expression of CCL22 is induced by IL4, IL13, and IFNG and inhibited by IL10. Increased expression CCL22 has also been observed after incubation of mast cells with TNF-alpha or IgE. CCL22 is chemotactic for chronically activated T-cells and plays a role in trafficking activated T cells. It also plays a role in migration and survival of cells expressing FOXP3. CCL22 is a ligand for CCR4.

CCL23 is a chemokine containing six conserved cysteine residues, two of which are adjacent. It is expressed in alveolar macrophages, dendritic cells, and endometrial stromal cells. It is also expressed in monocytes after induction with IL1B and IFNG. CCL23 is chemotactic for monocytes and resting T cells and is a suppressor of LPP-CFC myeloid progenitor cells. It is a ligand for CCR1, as well as the formyl peptide receptor FPR1.

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CCL24 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed by activated monocytes and activated T lymphocytes. CCL24 is chemotactic for eosinophils and resting T lymphocytes and is a suppressor of HPP-CFC myeloid progenitor cells. It causes a transient rise in intracellular calcium levels in eosinophils and is implicated in a variety of eosinophilic inflammatory diseases. CCL24 is a ligand for CCR3.

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

CCL24 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed by activated monocytes and activated T lymphocytes. Murine CCL24 is expressed in jejunum and spleen constitutively and is upregulated by allergen challenge and IL4 overexpression. CCL24 is chemotactic for resting T lymphocytes and eosinophils and is a suppressor of HPP-CFC myeloid progenitor cells. It causes a transient rise in intracellular calcium levels in eosinophils. CCL24 is a ligand for CCR3.

Rat CCL24 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed by activated monocytes and activated T lymphocytes. CCL24 is expressed in jejunum and spleen constitutively and is upregulated by allergen challenge and IL4 overexpression. CCL24 is chemotactic for resting T lymphocytes and eosinophils and is a suppressor of HPP-CFC myeloid progenitor cells. It causes a transient rise in intracellular calcium levels in eosinophils and is involved in a variety of eosinophilic inflammatory diseases. CCL24 is a ligand for CCR3.

CCL25 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed primarily in thymus and small intestine tissue. CCL25 is chemotactic for thymocytes, macrophages, and dendritic cells, as well as IgA antibody-secreting cells and is also a suppressor of myeloid progenitor cells. CCL25 is important for selective homing and retention of T cells in the small intestine instead of the colon and is possibly involved in T cell development. CCL25 is a ligand for CCR9 and ACKR4.

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!