Acidic FGF (FGF1), Human
GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
Recombinant Human Fibroblast Growth Factor 1
Endothelial cell growth factor
FGF1 is a member of the Fibroblast Growth Factor family of proteins. Also called FGF-acidic or aFGF, FGF1 lacks signal peptides and is believed to be secreted by a nonclassical mechanism. It has been detected in large amounts in the brain and is expressed in hepatocyte cells, vascular smooth muscle cells, CNS neurons, skeletal muscle cells, fibroblasts, keratinocytes, endothelial cells, intestinal columnar epithelial cells, and pituitary basophils and acidophils. FGF1 exhibits considerable species cross-reactivity and stimulates the proliferation of cells of mesodermal origin, as well as many cells of neuroectodermal, ectodermal, and endodermal origin. It is most closely associated with FGF2 (bFGF) (see additional information).
Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.
Source: Escherichia coli
MW: ~15.8 kDa (141 amino acids)
Purity: >95% by SDS-PAGE and HPLC analyses
Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine balb/c 3T3 cells is less than 0.5 ng/ml, corresponding to a specific activity of >2.0×106 IU/mg in the presence of 10 μg/ml of heparin.
Storage/Handling: Store desiccated at -20°C.
HGNC ID: 3665
NOT FOR HUMAN USE!
Additional resources for this protein may be found at:
|Storage/Handling||Store desiccated at -20°C.|
Informational resource handbook for various growth factors; their background, utilization and their receptor information.
Relative mitogenic activity of FGFs against FGF Receptors compared to FGF1 (aFGF).