Pepstatin A

Product Description

Pepstatin A is a competitive, reversible aspartic protease inhibitor and inhibits proteases such as pepsin, chymosin, renin, HIV proteases, and cathepsins D and E. Peptstatin A is highly selective and is often used in a mixture with other enzyme inhibitors. In vitro studies have shown pepstatin A is the only aspartic acid inhibitor that exhibits inhibitory effects on HIV proteases.

Pepstatin A is effective at inhibiting most affected proteases at a concentration of 1μM, but can inhibit pepsin at the picomolar range of concentrations. It is believed to function by way of a collected-substrate inhibition mechanism. Pepstatin A may also suppress differentiation of osteoclasts by inhibiting phosphorylation of MAP kinase and inhibiting NFATc1 expression.


Product Specifications
Pepstatin A

MOLECULAR BIOLOGY GRADE

Formula:C34H63N5O9

MW:685.89 g/mol

PubChem Chemical ID: 5478883

Storage/Handling: Store at 4°C.
Pepstatin A is soluble in acetic acid, DMSO, ethanol, and methanol

Product Specifications

Catalog ID P-020
CAS # 26305-03-3
MW 685.89 g/mol
Grade MOLECULAR BIOLOGY GRADE

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