Description
Cloxacillin sodium is a sodium salt formed from a chlorinated semisynthetic derivative of penicillin. It has been shown to exhibit significant bactericidal activity against penicillin G-resistant staphylococci.
Penicillins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a five-membered thiazolidine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Resistance to β-lactam antibiotics occurs in the presence of cells containing plasmid encoded extended spectrum β-lactamases or ESBLs.
Product Specifications
Cloxacillin sodium
Formula: C19H17ClN3NaO5S ∙ H2O
MW: 475.88 g/mol
Storage/Handling: Store at 4°C.
PubChem Chemical ID: 23675743
