Timentin™ Ticarcillin/Clavulanate (15/1)EZ Pak™ for 100 mg/mL Solution
Timentin™ is a 15:1 mixture of ticarcillin and clavulanate. Ticarcillin is a penicillin ß-lactam antibiotic, which is susceptible to ß-lactamase degradation. When combined with clavulanate, a ß-lactamase inhibitor, its efficacy is greatly increased. Timentin™ exhibits high activity against gram-negative bacteria and resistant Agrobacterium species.
Penicillins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a five-membered thiazolidine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Resistance to β-lactam antibiotics occurs in the presence of cells containing plasmid encoded extended spectrum β-lactamases or ESBLs.
The TimentinTM EZ PakTM is the fastest and easiest way to make a set amount of sterile TimentinTM solution. The kit includes pre weighed TimentinTM powder, a sterile filter, and a sterile container for the filtered solution. No need to calculate, simply add the stated amount of deionized H₂O, filter, and pour into the labeled bottle for easy usage. The EZ PakTM includes high quality GoldBio TimentinTM and the sterile solution is ready for tissue culture, bacterial media, or any number of uses.
The 50 ml and 100 ml packs include a vacuum manifold for easy vacuum filtering while 10 ml pack size comes with syringe filter.
TESTED AGAINST BOTH SENSITIVE AND RESISTANT CELLS AT GOLD BIOTECHNOLOGY LAB.
|CAS #||4697-14-7; 61177-45-5|
A brief explanation of the disk diffusion assay method used to test Gold Bio antibiotics
Potato-Agrobacterium Transformation using Kanamycin, Timentin and Zeatin - by Hui Duan et al. (2012)