Cefmetazole Sodium

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Description

Cefmetazole is a semisynthetic second generation cephalosporin antibiotic derived from cephamycin. It is effective against a variety of gram-negative and gram-positive bacteria, exhibiting more efficacy against many gram-negative enteric bacteria than many first generation cephalosporins. In addition, cefmetazole has been used to research its effect on the expression and inhibition of the penicillin binding proteins, especially PBP2 and PBP4.

Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.


Product Specifications
Cefmetazole Sodium
Cefmetazole Sodium Salt

MOLECULAR BIOLOGY GRADE

Formula: C15H16N7O5S3Na

MW: 493.52 g/mol

Storage/Handling: Store at 2-8 °C. Store under inert gas.

PubChem Chemical ID: 23666711

Cefmetazole Sodium

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Catalog Number:
C-631-1
CAS Number:
56796-39-5
$111.00

For research use only. Not for food, drug, household, or cosmetic use.
Availability:
2-3 Weeks
Shipping:
$14.99 Ground shipping (In continental US only.)

    Description

    Cefmetazole is a semisynthetic second generation cephalosporin antibiotic derived from cephamycin. It is effective against a variety of gram-negative and gram-positive bacteria, exhibiting more efficacy against many gram-negative enteric bacteria than many first generation cephalosporins. In addition, cefmetazole has been used to research its effect on the expression and inhibition of the penicillin binding proteins, especially PBP2 and PBP4.

    Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.


    Product Specifications
    Cefmetazole Sodium
    Cefmetazole Sodium Salt

    MOLECULAR BIOLOGY GRADE

    Formula: C15H16N7O5S3Na

    MW: 493.52 g/mol

    Storage/Handling: Store at 2-8 °C. Store under inert gas.

    PubChem Chemical ID: 23666711

    Product Specifications

    Catalog ID: C-631
    CAS #: 56796-39-5
    MW: 493.52 g/mol
    Grade: MOLECULAR BIOLOGY GRADE
    Storage/handling: Store at 4°C.
    PubChem Chemical ID: 23666711
    IUPAC Name: sodium (6R,7S)-7-[[2-(cyanomethylsulfanyl)acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    InChI: InChI=1S/C15H17N7O5S3.Na/c1-21-14(18-19-20-21)30-6-8-5-29-13-15(27-2,17-9(23)7-28-4-3-16)12(26)22(13)10(8)11(24)25;/h13H,4-7H2,1-2H3,(H,17,23)(H,24,25);/q;+1/p-1/t13-,15+;/m1./s1
    InChIKey: BITQGIOJQWZUPL-PBCQUBLHSA-M
    SMILES: CN1C(=NN=N1)SCC2=C(N3C(C(C3=O)(NC(=O)CSCC#N)OC)SC2)C(=O)[O-].[Na+]

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