BMP & Noggin

Bone Morphogenetic Proteins are growth factors that were originally found to help induce the formation of bone and cartilage but also regulate tissue architecture throughout the body. The absence or misregulation of BMP signaling has been linked in the progression of various cancer types, including bone and colon. Noggin proteins are signal transducers which are integral inhibitors for many proteins in the TGF (Transforming Growth Factor) family, including BMP4, and are crucial in cognition, bone development, joint formation and neurulation. GoldBio’s high quality recombinant proteins have a purity level exceeding 95% in most cases and also have excellent bioactivity with low endotoxin levels.

Showing 1-5 of 5 items.

BMP2, Human

Catalog ID Size Pricing
1180-02-2 2 μg $ 76.00
1180-02-10 10 μg $ 112.00
1180-02-100 100 μg $ 574.00
1180-02-250 250 μg $ 904.00
1180-02-500 500 μg $ 1,483.00
1180-02-1000 1000 μg $ 2,343.00

Description

Bone Morphogenetic Proteins (BMPs) belong to the TGF-β (Transforming Growth Factor) superfamily of structurally related signaling proteins. BMP2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition, BMP2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues; including the lung, spleen, brain, liver, prostate, ovary and small intestine. The functional form of BMP2 is a 26kDa protein composed of two identical 115 amino acid polypeptide chains linked by a single disulfide bond.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Product Specifications

Catalog ID 1180-02
MW ~26.0 kDa
Storage/Handling Store desiccated at -20°C.
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1180-02-2 2 μg $ 76.00
1180-02-10 10 μg $ 112.00
1180-02-100 100 μg $ 574.00
1180-02-250 250 μg $ 904.00
1180-02-500 500 μg $ 1,483.00
1180-02-1000 1000 μg $ 2,343.00

BMP4, Human Inactive Protein

Catalog ID Size Pricing
1180-04-2 2 μg $ 76.00

Description

Bone Morphogenetic Proteins (BMPs) belong to the TGF-β (Transforming Growth Factor) superfamily of structurally related signaling proteins. BMP4 is one of at least 15 structurally and functionally related BMPs originally identified as protein regulators of cartilage and bone formation. They have since been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs have been shown to regulate the growth, differentiation, chemotaxis and apoptosis of a variety of cell types; including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. The active form of BMP4 can consist of a dimer of two identical proteins or a heterodimer of two related BMPs. BMP4 is essential for various processes in early development, beginning with gastrulation and mesoderm formation.

Product Specifications

Catalog ID 1180-04
MW ~13.0 kDa
Storage/Handling Store desiccated at -20°C.
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1180-04-2 2 μg $ 76.00

BMP7, Human Inactive Protein

Catalog ID Size Pricing
1180-07-2 2 μg $ 76.00
1180-07-10 10 μg $ 112.00
1180-07-1000 1000 μg $ 701.00

Description

Bone Morphogenetic Proteins (BMPs) belong to the TGF-β (Transforming Growth Factor) superfamily of structurally related signaling proteins. BMP7 is one of at least 15 structurally and functionally related BMPs, originally identified as protein regulators of cartilage and bone formation which have since been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs have been shown to regulate the growth, differentiation, chemotaxis and apoptosis of a variety of cell types; including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. The active form of BMP7 can consist of a dimer of two identical proteins or a heterodimer of two related BMPs. BMP7 is expressed highest in the kidneys and is genetically linked in mice to eye, skeletal and kidney development.

Product Specifications

Catalog ID 1180-07
MW ~15.6 kDa
Storage/Handling Store desiccated at -20°C.
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1180-07-2 2 μg $ 76.00
1180-07-10 10 μg $ 112.00
1180-07-1000 1000 μg $ 701.00

Noggin, Human

Catalog ID Size Pricing
1180-09-5 5 μg $ 76.00
1180-09-20 20 μg $ 112.00
1180-09-100 100 μg $ 394.00
1180-09-250 250 μg $ 723.00
1180-09-500 500 μg $ 1,080.00
1180-09-1000 1000 μg $ 1,795.00

Description

Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-β (Transforming Growth Factor) family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Noggin has been shown to modulate the activities of other BMPs including BMP2, 7, 13, and 14. Targeted deletion of noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Transgenic mice over-expressing noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation and severe osteoporosis.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Product Specifications

Catalog ID 1180-09
MW ~46.2 kDa
Storage/Handling Store desiccated at -20°C.
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1180-09-5 5 μg $ 76.00
1180-09-20 20 μg $ 112.00
1180-09-100 100 μg $ 394.00
1180-09-250 250 μg $ 723.00
1180-09-500 500 μg $ 1,080.00
1180-09-1000 1000 μg $ 1,795.00

Noggin, Murine

Catalog ID Size Pricing
1380-09-5 5 μg $ 76.00
1380-09-20 20 μg $ 112.00
1380-09-100 100 μg $ 394.00
1380-09-250 250 μg $ 723.00
1380-09-500 500 μg $ 1,080.00
1380-09-1000 1000 μg $ 1,795.00

Description

Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-β (Transforming Growth Factor) family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Noggin has been shown to modulate the activities of other BMPs including BMP2, 7, 13 and 14. Targeted deletion of noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Transgenic mice overexpressing noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis.

Product Specifications

Catalog ID 1380-09
MW ~46.4 kDa
Storage/Handling Store desiccated at -20°C.
View
Quick Add
1380-09-5 5 μg $ 76.00
1380-09-20 20 μg $ 112.00
1380-09-100 100 μg $ 394.00
1380-09-250 250 μg $ 723.00
1380-09-500 500 μg $ 1,080.00
1380-09-1000 1000 μg $ 1,795.00

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